Choline acetyltransferase
| Choline acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifier | |||||||||
| EC number | 2.3.1.6 | ||||||||
| CAS registration number | 9012-78-6 | ||||||||
| Database | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA () | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structure | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Gene オントロジー | AmiGO / EGO | ||||||||
| |||||||||
Choline acetyltransferase (choline acetyltransferase: abbreviated designation ChAT) is the enzyme which commits acetyl CoA and Colin when I compose the acetylcholine which is a neurotransmitter as a substrate. I am composed in nerve cells, and it is progressed in the nerve terminals by axon transportation. In the Homo sapiens, the choline acetyltransferase is encoded by CHAT gene [1].
Function
The cholinergic nervous system participates in various nerve activity. It is shown in the Alzheimer's dementia and Levy corpuscle type dementia patients that the function of the cholinergic nerve decreases. I am shown that choline acetyltransferase has decreased it from the early days in the Levy corpuscle type dementia patients [2].
Footnote
- ^ Strauss WL, Kemper RR, Jayakar P, Kong CF, Hersh LB, Hilt DC, Rabin M (February 1991). "Human choline acetyltransferase gene maps to region 10q11-q22.2 by in situ hybridization." Genomics 9 (2): 396–8. doi: 10.1016/0888-7543(91)90273-H. PMID 1840566.
- ^ Tiraboschi P, Hansen LA, Alford M, Merdes A, Masliah E, Thal LJ, Corey-Bloom J (October 2002). "Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease.." Arch Gen Psychiatry 59 (10): 946–51. PMID 12365882.
Allied item
This article is taken from the Japanese Wikipedia Choline acetyltransferase
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