Sideropenic anemia
| Sideropenic anemia | |
|---|---|
 | |
| A classification and outside reference information | |
| ICD-10 | D50 |
| ICD-9-CM | 280 |
| DiseasesDB | 6947 |
| eMedicine | med/1188 |
| MeSH | D018798 |
Sideropenic anemia (てつけつぼうせいひんけつ British: iron deficiency anemia, IDA) is anemia to occur in what cannot produce hemoglobin enough by iron being short in the body.
Table of contents
Condition of a patient
The red blood cell contains Hb (hemoglobin, Hb) in a cell, and iron is one of the required ingredients constituting Hb. It is existence があればこそである of iron Hb connects oxygen, and to be able to carry. It is anemia that life cannot compose enough Hb and occurs by iron being short in the body. Because the red count is often in the normalcy area, the complexion elementary quality included in one one red blood cell decreases (hypochromia characteristics). In addition, the size is smaller than normal erythroblast although a number in the red marrow increases the hematoblast which is the outrider cell of the red blood cell (in other words, small erythroblast is made in large quantities); [1].
- I produce bleeding regularly, but, as for the woman of the reproductive age, iron included in the red blood cell is exhausted outside a body on this occasion by menstruation, too. Therefore the woman is apt to lack iron content basically.
- When young women do not take in iron of the necessary quantity by unbalanced diet and impossible weight loss, it is easy to fall into sideropenic anemia.
- The example which an existing woman of the myoma of the uterus becomes near the menopause, and amounts of bleeding increase, and becomes sideropenic anemia is frequent.
- Gastrointestinal bleeding such as a gastric ulcer, stomach cancer, hemorrhoids, colon cancer may cause the iron lack. As for right half colon cancer in particular, sideropenic anemia may be the only symptom. I am rarely bleeding for other malignant tumors chronically and may produce sideropenic anemia. I often doubt in particular the chronic bleeding from gastrointestinal tract when the man who does not have an unbalanced diet is sideropenic anemia.
The diagnosis of sideropenic anemia is not very difficult, but it is necessary to search a cause in a diagnosis, treatment as follows and checks presence of the bleeding, a bleeding source on this occasion. It was an extra, but the parasitic worms such as a roundworm or hookworm disease seemed to be big causes before World War II, too.
The symptom of the anemia public refers to anemia.
Cause
When the receipt and disbursement of iron is inclined to the loss side, it takes place. However, there is not it with sideropenic anemia because a spare (storage iron) of iron exists in the body until this storage iron dries up.
Loss to the outside the body of iron
It takes place to lose iron of materials by chronic bleeding. The condition of a patient to lose a red blood cell chronically includes the following things.
- There are relatively too more frequency and quantity of menorrhagia - menstruation than hematopoietic efficacy.
- Malignant tumor - particularly gastrointestinal tumor is often accompanied by bleeding and causes a red blood cell, the iron loss.
- A representative disease to result in long-term bleeding other than ulcerative colitis - tumor.
lacking in intake of iron
When an iron intake is short by unbalanced diet and impossible weight loss, it causes sideropenic anemia.
Malabsorption of iron
When I remove stomach surgically by an operation and perform enteric large-scale excision, absorption of iron becomes difficult.
Sudden increase of the quantity of use of iron
When iron is used other than synthesis of hemoglobin in large quantities.
Statistics
- The onset age is common in young - middle-ages.
- The sex differences are common in women. Because the woman loses a red blood cell with menstruation regularly, it is easy to fall into anemia in comparison with a man.
- There is the most onset frequency in anemia.
Symptom
- The main subjective symptoms have an anemia symptom such as easy fatigue (fatigable), a heartbeat, ringing in the ears, dizziness, a feeling of dyspnea, an appetite looking pale coming off. I cannot get up if I become terrible.
- In addition, a fingernail (nail) warps as a special symptom upward. A spoon nail (さじじょうそう), a spoon nail (British: spoon nail) mean that a fingernail (nail) warps upward.
- The palpebral conjunctiva becomes pale.
Complications
- Plan mer Vinson syndrome（Plummer-Vinson syndrome、英: Plummer-Vinson syndrome）
- The syndrome that the plan mer Vinson syndrome assumes glossitis, angular stomatitis, dysphagia three signs.
- The condition of a patient
- Because the mucous membrane cell needs iron for cell metabolism, I am complicated with plan mer Vinson syndrome.
- Symptom
- The three major symptoms are glossitis, angular stomatitis, dysphagia.
- Pica (atomic bomb)
- The compulsive chronic symptom to take in of the specific non-nourishment material. There are many quantity that is abnormal in ice in particular, cases of the glacial erosion symptom eating.
Inspection
- Blood test
Typical test result pattern
- Hb (hemoglobin) Drop
- Ht (hematocrit) drop
- MCV (the mean red blood cell capacity) Drop
- MCH (quantity of mean red blood cell pigment) drop
- Fe (serum iron) Drop
- Ferritin Drop
- TIBC Rise
-
- Serum biochemical profile
- Because iron lacks, serum iron decreases, and serum ferritin (I reflect quantity of storage iron) decreases. In addition, total iron binding capacity (TIBC), unsaturated iron binding capacity (UIBC) rise.
- Examination with peripheral blood smear dyeing specimen
- If hematopoietic efficacy is kept, there is relatively much number of red blood cells and the contents are relatively short and present with prill-related hypochromic anemia. As for the red blood cell, the contents decrease and become very thin. The red blood cell which became very thin is called 菲薄赤血球. A red blood cell of various size is seen. A red blood cell of various size is called a red blood cell of the big things and small things inequality. 菲薄赤血球 of the big things and small things inequality is seen. In addition, the reticulocyte decreases, too (it may be normal numerically).
- Serum biochemical profile
- The research of the cause disease that I spoke earlier is necessary (gastrointestinal inspection such as fecal occult-blood testing, endoscope, gynecology consultation).
Treatment
When there is a cause disease, I give that treatment.
Degree of anemia is not serious and gives meal instruction and the iron medicine dosage (oral, intravenous injection) if not in condition to endanger life. Absorption factor of iron slightly rises when I take in vitamin C together when it is oral. I gradually in this way go to the recovery because a red blood cell containing the hemoglobin has been made enough if hematopoietic efficacy is normal. But I continue giving iron medicine for a while because storage iron dries up when I suffer from sideropenic anemia in order to usually revive storage iron even if sideropenic anemia recovers.
When I may endanger life for serious anemia, a blood transfusion is necessary. When side effects such as the gastrointestinal symptom may be strong or the oral iron medicine is expected by a person by some kind of causes if absorption of the oral iron medicine is bad, an intravenous injection is necessary for (after gastrointestinal excision), but it needs attention to the dosage gross weight because the iron medicine dosage of the excessive quantity may invite iron composure (necessary iron quantity [mg] = (2.7* (16-Hb) +17) X BW where I often use an expression of Nakao for for a calculation of the dosage gross weight).
Source
- ^ Shunzo Onishi, Hiroki Kajihara, Ryuichi Kamiyama editing "standard pathology" (the second edition) p.408 sentence Amitabha hall March 30, 2004 publication ISBN 4-8306-0449-2
Allied item
This article is taken from the Japanese Wikipedia Sideropenic anemia
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