Amoxapine
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| Material name by the IUPAC glossology | |
|---|---|
| 8-chloro-6-piperazin-1-ylbenzo[b][1, 4]benzoxazepine | |
| Clinical data | |
| Sale name | Ethical drug search |
| Dosage method | Oral administration |
| Pharmacokinetics data | |
| Plasma protein combination | 90.0 |
| Half-life | 8 hour |
| Excretion | Urine 47% |
| Identification | |
| CAS number (MeSH) | 14,028-44-5 |
| ATC cord | N06AA17 (WHO) |
| PubChem | CID: 2170 |
| DrugBank | APRD00142 |
| KEGG | D00228 |
| Chemical data | |
| Chemical formula | C17H16ClN3O |
| Molecular weight | 313.7810 |
| |
| Physical data | |
| Melting point | 178 degrees Celsius (352 degrees Fahrenheit) |
Amoxapine (English: Amoxapine) is a compound used as antidepressant. I am known as the second generation tricyclic antidepressant, and anticholinergic action is reduced. I am sold in the name of the Amo xanthan gum in Japan, and the adaptation is depression, a depressed mental state. Prescription pharmaceutical products、Powerful drugである. In 1963, I was composed by Swiss J.Schmutz.
By anticholinergic action, I am constipated in 口渇, thereunder than 5%, and I examine dysuria, and adjustment obstacles occur, and emotion uneasiness, chills, confusion or other symptoms may produce it by the rapid decrease of the dose [1].
Table of contents
Synthetic
In 1963, I was composed by Swiss J.Schmutz and was developed in Lederie Institute of American Cyanamid () ().
Reactions of drugs
I provide the noradrenaline to the nerve terminal in the brain and reuptake inhibition of the serotonin.
The 7-hydroxy body of the active metabolite has strong dopamine D2 receptor block action. By the action of this metabolism thing, extrapyramidal sign (EPS) similar to antipsychotic and a malignant syndrome may appear at the high dose. The 8-hydroxy body has strong noradrenaline reuptake inhibition action.
The blood concentration reduction by half of the 7-hydroxy body is approximately 6.5 hours, and the blood concentration reduction by half of the 8-hydroxy body is approximately 30 hours.
The muricide restraint action is stronger than imipramine and amitriptyline, and it has action to control excessive emotion generally by the megadose. In addition, I have the action such as the restraint of the self-motion and the cataleptic creation.
It is N metabolism product to demethylate of loxapine () of the non-fixed form antipsychotic.
Adaptation
The adaptation in Japan is depression, a depressed mental state.
Contraindicated
- Acute narrow corners-cut square (occlude corners-cut square) glaucoma
I might cause an attack by mydriasis by the anticholinergic action.
- The early period of recovery of myocardial infarction
A condition might be exacerbated by the heart toxicity such as heart conduction disorders.
- It is a patient within two weeks after in the dosage or the dosage cancellation with a monoamine oxidizing enzyme (MAO) inhibitor
contraindicated to combination
- I reinforce action in monoamine oxidizing enzyme (MAO) inhibitor - aspect each other, and the monoamine density in the brain might increase.
In addition, combination attention includes SSRI. These inhibit metabolism of amoxapine, and blood concentration rises mutually, and action may be reinforced.
It is to be able to say to the most of the drug metabolized in liver, but the combination with the alcohol might invite an unexpected side effect.
Side effect
In the clinical trial, I am constipated by anticholinergic action in 口渇, 0.1-5% than 5%, and I examine dysuria, and within it, oliguria, rhinostenosis, intraocular pressure sthenia produce adjustment disorder, 0.1% [1].
Because emotion uneasiness, chills, confusion, a headache, a sleep disorder, lassitude, feeling like vomiting, sweat may appear by a rapid decrease and the cancellation of the dose, I gradually lose weight and perform the cancellation of the dosage carefully [1].
- Lassitude, a feeling of weakness, a concentration drop, sleepiness, a headache, dizziness feel dizzy and affect constipation, liver function
- Anticholinergic side effect - anticholinergic side effect is the symptom that is frequent in tricyclic system antidepressant. At the tip, I include 口渇, constipation, paralytic ileus, anuria, induction of the acute narrow corners-cut square glaucoma and, in the center, include defects of memory, confusion, 妄, a hallucination, hyperpyrexia not to do.
- Extrapyramidal sign (EPS) - As for the active metabolite of amoxapine, EPS may emerge to intercept dopamine D2 receptor. It is premature and includes parkinsonism, dystonia, akathisia, JIS Quinet dia, but is not brought into question by the clinical practice in particular. It is very rare, but tardive parkinsonism, tardive akathisia, tardive dystonia, tardive JIS Quinet dia (the abnormal involuntary movement around the mouth and quiver of the tongue) may get up when I take the long term at a high dose.
- It is rare, but EPS, disturbance of consciousness with the high heat may happen for malignant syndrome - emergency.
Kind
In Japan, I am manufactured from a brand name of the Amo xanthan gum alone from Pfizer and am sold. The patent expires, but is not released generic は.
- A capsule: 10 mg, 25 mg, 50 mg
- An infinitesimal grain: 10%
Footnote
This article is taken from the Japanese Wikipedia Amoxapine
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