Tetrahydroxynaphthalene reductase

Tetrahydroxynaphthalene reductase
Identifier
EC number	1.1.1.252
CAS registration number	153,702-05-7
Database
IntEnz	IntEnz view
BRENDA (English version)	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structure	RCSB PDB PDBe PDBj PDBsum
Gene オントロジー	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Tetrahydroxynaphthalene reductase (tetrahydroxynaphthalene reductase) is an oxidation-reduction enzyme catalyzing the next chemical reaction.

シタロン + NADP⁺ ${\displaystyle \rightleftharpoons}$ 1,3,6,8-tetrahydroxynaphthalene + NADPH + H⁺

According to the equation, as for the substrate of this enzyme, シタロン and NADP⁺, a product are 1,3,6,8-tetrahydroxynaphthalene and NADPH and H⁺.

The organization name is scytalone:NADP⁺δ⁵-oxidoreductase.

References

• Wheeler MH and Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease." Exp. Mycol. 12: 151–160. doi: 10.1016/0147-5975(88) 90,004-7. 
• Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M (1994). "Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing." Eur. J. Biochem. 219: 985–92. doi: 10.1111/j.1432-1033.1994.tb18581.x. PMID 8112349. 
• Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB (1997). "Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism." Biochemistry. 36: 1852–60. doi: 10.1021/bi962355u. PMID 9048570. 

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