Mazindol
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| Material name by the IUPAC glossology | |
|---|---|
| (±) -5-(4-chlorophenyl) -3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol | |
| Clinical data | |
| Drugs.com | Micromedex Detailed Consumer Information |
| Legal regulation |
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| Dosage method | Oral |
| Pharmacokinetics data | |
| Bioavailability | 93% |
| Metabolism | Hepatic |
| Half-life | 10-13 hours |
| Excretion | Renal |
| Identification | |
| CAS number (MeSH) | 22,232-71-9  |
| ATC cord | A08AA05 (WHO) |
| PubChem | CID: 4020 |
| IUPHAR/BPS | 4797 |
| DrugBank | DB00579 |
| ChemSpider | 3880 |
| UNII | C56709M5NH |
| KEGG | D00367 |
| ChEMBL | CHEMBL781 |
| Chemical data | |
| Chemical formula | C16H13ClN2O |
| Molecular weight | 284.74 g/mol |
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Mazindol (Mazindol) is an anorexigenic agent. It is approved for an anorexigenic agent alone in Japan, and, as of 2007, I am sold with a brand name of Sanorex by Novartis Pharma. Adaptation is only altitude adiposity when an effect of a diet cure and the kinesitherapy is insufficient [1]. In addition, I am appointed to the customariness pharmaceutical products in the law about quality, the effective and safe securing of pharmaceutical products, medical equipment [2]. It is a powerful drug [3].
The pharmacologic characteristic is similar to amphetamine which is a stimulant. It is sympathetic nerve action amine controlling an appetite with energy consumed promotion by direct action to the appetite center and adrenalin, dopamine in the brain, two kinds of mechanism called the reuptake restraint due to nerve cells of the serotonin.
There are dependent possibility by the animal experiment and the resistant expression in the short term, and it is said that the dependence in people is not clear [3]. The dependence of the metrazol (stimulant) is psychic dependence and tolerance [3]. As for the dosage in the health insurance adaptation, three months are considered to be a limit.
In addition, when, as a taboo, there are mental disorders such as uneasiness, dejection, abnormal excitement or schizophrenia in the past of alcohol, the drug dependency; with others, some medical diseases [3].
Regulation
In an international treaty to regulate an abuse drug, the treaty about the psychotropic drug, I am appointed in a drug of schedule IV [4].
Source
- With the ^ altitude adiposity, degree of corpulence is more than 35 in more than +70% or the body mass index (BMI).
Degree of corpulence (%) = (true weight - normal weight) / normal weight *100
BMI = weight (kg )÷( height (m) X height (m)) - ^ Ministry of Health and Welfare, "notice of pharmaceutical products text (press release) which the Minister of Health, Labour and Welfare appoints as a thing with the customariness based on a rule of the Drugs, Cosmetics and Medical Instruments Act Article 50 ninth", Ministry of Health, Labour and Welfare1 February 16, 2014 reading.
- ^ a b c d Novartis Pharma 2013.
- ^ * Masaaki Matsushita (total editing) "IV international psychotropic drug treaty" "drug, alcohol-related obstacle" editing: In Sadanobu Ushijima, Tsukasa Koyama, Isamine Miyoshi, Masahiro Asai, Masayoshi Kurachi, Yoshibumi Nakane, Nakayama Bookstore 〈 clinical psychiatrical lecture 8>, June, 1999, it is 109-123 pages. ISBN 978-4,521,492,018。
References
- Novartis Pharma (2013-04) (pdf). Sanorex lock 0.5mg(Report). It is reading Japan Pharmaceutical Information Center on f February 16, 2014. .
This article is taken from the Japanese Wikipedia Mazindol
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