Clonidine
 | |
| Material name by the IUPAC glossology | |
|---|---|
| N-(2,6-dichlorophenyl) -4,5-dihydro-1H-imidazol-2-amine | |
| Clinical data | |
| Fetus degree of risk classification |
|
| Legal regulation |
|
| Dosage method | Pass through oral; skin |
| Pharmacokinetics data | |
| Bioavailability | 75-95% |
| Plasma protein combination | 20-40% |
| Metabolism | Liver |
| Half-life | 12-33 hours |
| Excretion | Kidney (40-50%) |
| Identification | |
| CAS number (MeSH) | 4205-90-7 |
| ATC cord | C02AC01 (WHO) N02CX02 (WHO), S01EA04 (WHO) |
| PubChem | CID: 2803 |
| DrugBank | APRD00174 |
| KEGG | D00281 |
| Chemical data | |
| Chemical formula | C9H9Cl2N3 |
| Molecular weight | 230.093 g/mol |
The drug that clonidine (British: Clonidine) is used for treatment of the high blood pressure. I belong to selective α 2 receptor agonist pharmacologically. The brand name "Catapres" (Boehringer Ingelheim production sale)
I control the excitement of the preganglionic fiber by acting on α 2 receptor which is the subtype of the adrenergic receptor selectively and reduce blood pressure by controlling secretion of the noradrenaline.
Action is strong, and there is long α receptor blockade at action time and is less used for treatment itself of the high blood pressure too much now. I may be used as a load drug in the load examination of the phaeochromocytoma traditionally.
Table of contents
Effect, effect
Various high blood pressure [1]
Allied item
Source
- ^ "150 μg of Catapres Tablets 75μg/ Catapres Tablets". August 31, 2015 reading.
Outside link
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