I consist of the subunits of four structure of the catalase.
Protein structure data bank Molecules 057 of this month a catalase (Catalase):
|CAS registration number||9001-05-2|
|BRENDA ( )||BRENDA entry|
|PDB structure||RCSB PDB PDBe PDBj PDBsum|
|Gene オントロジー||AmiGO / EGO|
The enzyme which catalyzes a reaction that dismutation does hydrogen peroxide in catalase (catalase) and changes to oxygen and the water. It is a kind of the hemoprotein and includes protoheme. There is it to intracellular peroxisome and performs the oxidation, detoxification using hydrogen peroxide.
French chemist Louis Thenard (I discover it in 1818) who was a detector of hydrogen peroxide noticed that a certain material known as a catalase raised resolution speed of hydrogen peroxide. It is German agriculture chemist Oscar Loew to have named this material a catalase . It is Walter A. that it isolates a catalase, and it decided American chemist James Sumner, the amino acid sequence of the catalase to have crystallized It is Schroeder and others.
The metabolism number of revolutions per every second is the highest in all enzymes and reaches 40 million . In the case of Homo sapiens, the catalase is comprised of four subunits; each subunit consisting of 526 amino acids . The molecular weight is approximately 240,000. I use heme and manganese as cofactor.
Because there is a lot it to liver including Homo sapiens, oxygen is generated when I add liver to oxydol. In the case of Homo sapiens, there is the gene encoding this protein in p13 of the eleventh chromosome in CAT. In addition, acatalasia develops when this gene suffers a loss.
As for optimal pH, approximately 7.0, the optimal temperature are 37 degrees Celsius. It functions catalytically by lowering the activation energy of the following reactions.
- 2 H2O2 → O2 +2 H2O
The ability of the Mii Delaware garbage insect jetting high temperature gas depends on the high metabolism number of revolutions of the catalase. In addition, it is very important and can distinguish it by a catalase test whether bacteria have this enzyme in identifying bacteria. When I mixed oxygenated water (oxydol) so that there is many it if there is much content of the catalase, it is faster and can produce much oxygen.
- It is Vol. 11 no. 279 pp. ^ "A NEW ENZYME OF GENERAL OCCURRENCE IN ORGANISMIS",Science 4 May 1900 701-702
- For textbook Vol. 1 cell biology of the university biology for the ^ color illustration United States, David Sadava others, Kodansha, 2,010 years, it is p.18.
- It is 232-234 (pdf) ^ A Hirono et al."A Novel Human Catalase Mutation (358 T6del) Causing Japanese-type Acatalasemia," Blood Cells, Molecules, and Diseases (1995) 21(23) Dec 15
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