Benzylpenicillin

Penicillin G

Material name by the IUPAC glossology
IUPAC name (2S,5R,6R) -3,3-dimethyl-7-oxo-6-(2-phenylacetamido) -4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a685013
Fetus degree of risk classification	US: B
Legal regulation	℞ (Prescription only)
Dosage method	Parenteral
Pharmacokinetics data
Plasma protein combination	60%
Metabolism	Liver
Half-life	30 minutes
Excretion	Kidney
Identification
CAS number (MeSH)	61-33-6 (free acid) 69-57-8 (sodium salt)
ATC cord	J01CE01 (WHO) S01AA14 (WHO)QJ51CE01 (WHO)
PubChem	CID: 5904
DrugBank	DB01053
ChemSpider	5693
UNII	Q42T66VG0C
KEGG	D02336
ChEBI	CHEBI: 18208
ChEMBL	CHEMBL29
Chemical data
Chemical formula	C16H18N2O4S
Molecular weight	334.4 g/mol
SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)Cc3ccccc3)C(=O)O)C
InChI InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1 Key:JGSARLDLIJGVTE-MBNYWOFBSA-N

The benzylpenicillin (benzylpenicillin) is a kind of highest quality (gold standard (English version)) penicillin. Generally, I am known as penicillin G. Because it is unstable, I am usually given penicillin G by a non-oral route for the hydrochloric acid of the stomach. I can achieve the density (in other words, active an antimicrobe) in the organization which is higher than phenoxymethylpenicillin (Phenoxymethylpenicillin) to be given it parenterally.

Table of contents

Medical use

The adaptation of the benzylpenicillin with the following [¹].

• Cellulitis
• Bacterial endocarditis
• Gonorrhea
• Meningitis
• Aspiration-related pneumonia（English version), the lungsAbscess
• Community-acquired pneumonia
• Syphilis
• Sepsis of the child
• Sepsis-related joint pain (English version)
• Milk-related diarrhea
• Gangrene

Side effect

A neurologic symptom, serious colitis with blood in stool such as the pseudomembranous colitis, toxic epidermis necrosis myelinolysis, hemorrhagic cystitis such as a renal damage, convulsions that a shock, hemolytic anemia, agranulocytosis, acute renal failure are serious for a side effect rarely with fever, a rash, hives, an acidophile increase, granulocytopenia, thrombopenia, anemia, a rise in AST (GOT), a blood vessel ache, phlebitis [²].

Toxic

I can observe the serum levels of the benzylpenicillin by a traditional microbiologic assay or a newer chromatographic technique. Such measurement is useful in order to avoid the central nervous system toxicity in a patient given a high-dose drug habitually, but, as for this toxicity, a drug is particularly related to the patient of the concentrated kidney injury for a drop of urinary excretion speed [³]; [⁴].

公定地位

• Pharmacopoeial the U.K. (English version); [⁵]

Footnote

1. ^ Rossi S, ed. (2006), Australian Medicines Handbook, Adelaide: Australian Medicines Handbook, ISBN 0-9757919-2-3 
2. ^ "benzylpenicillin potassium." September 14, 2015 reading.
3. ^ Fossieck B Jr, Parker RH (1974). "Neurotoxicity during intravenous infusion of penicillin. A review." J. Clin. Pharmacol. 14 (10): 504-512. PMID 4610013. 
4. ^ R. Baselt (2008). Disposition of Toxic Drugs and Chemicals in Man (8th edition ed.). Foster City, CA: Biomedical Publications. pp. pp. 1195-1196. ISBN 978-0-9626523-7-0. 
5. ^ British Pharmacopoeia Commission Secretariat. "Index (BP 2009)". March 26, 2010 reading.

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