Aquala
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Aquala (lye ARA) is Kyocera medical の trademark about the technique that a graft polymerizes 2-methacryloyloxyethyl phosphorylcholine (MPC) in a prosthetic slide aspect. The frictional resistance with the slide aspect decreases in the artificial joint which I applied a lye ARA technology to and controls outbreak of the abrasion powder with sliding.
Table of contents
Summary
The main cause of the prosthetic "slack" is to the abrasion powder occurring from a joint slide aspect. Professor Kazuhiko Ishihara of the Tokyo University graduate school engineering system graduate course material engineering specialty, the Yoshio Takatori special appointment professor and others of the Tokyo University graduate school medicine system graduate course improved lubricity by a graft polymerizing 2-methacryloyloxyethyl phosphorylcholine (MPC) [1] in the slide aspect of the artificial joint, and building the class of MPC polymers for a joint slide interview and succeeded in restraint of the abrasion powder which occurred from the slide aspect of the artificial joint. [2]This technique is Aquala (lye ARA). The phosphorylcholine (phosphorylcholine) basis included in the MPC is structure same as a polar group of the phosphatide constituting a cell membrane. Fluid lubrication mechanism works that the MPC polymer layer includes body fluid in vivo and makes it a gel form in the artificial joint which I applied Aquala (lye ARA) technique to, and there is little frictional resistance, sliding is enabled like joint cartilage. In a simulation examination in imitation of a walk of the Homo sapiens, the frictional resistance under moisturizing it reduced it in lower than 1/10 in comparison with an artificial joint of non-processing in the artificial joint which I applied Aquala (lye ARA) technique to, and the number of the abrasion powder was restrained more than 99% again [3]. The Aquala (lye ARA) technique is established as the Japan's original material technology which prosthetic service life can largely lengthen and is already applied clinical practice to the total hip prosthesis equipped with this and is expected worldwide [4].
History, history
- I succeed in the development of the mass composition method of the MPC (2-methacryloyloxyethyl phosphorylcholine) in 1987 (Ishihara K, Polym J 1990)
- Full-scale industrial production start of 1999 MPC and the MPC polymer
- The prosthetic development that applied an MPC polymer in 1999 starts
- I carry out the clinical clinical trial of the MPC graft polymerization treated total hip prosthesis in a slide aspect in 2007
- It produces it to an MPC graft polymerization treated total hip prosthesis in 2011 and approves it (start of the clinical use of Aquala)
References
Moro T, Takatori Y, Ishihara K, Nakamura K, Kawaguchi H. 2006 Frank Stinchfield Award: Grafting of biocompatible polymer for longevity of artificial hip joints. Clin Orthop Relat Res 2006;453:58–63.
Moro T, Kawaguchi H, Ishihara K, Kyomoto M, Karita T, Ito H, Nakamura K, Takatori Y. Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: comparisons with the effect of polyethylene cross-linking and ceramic femoral heads. Biomaterials 2009, 30 (16): 2995–3001.
Footnote
- ^ Ishihara K. Preparation of phospholipid polymers and their properties as polymer hydrogel membranes. Polym J 1990, 22 (5): 355–360.
- ^ Moro T, et al. Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis. It is 829-836, 2004 Nat Mater 3.
- ^ Kyomoto M, et al. Effects of mobility/immobility of surface modification by 2-methacryloyloxyethyl phosphorylcholine polymer on the durability of polyethylene for artificial joints. It is 362-371, 2009 J Biomed Mater Res A 90.
- ^ Takatori Y, et al. Clinical and radiographic outcomes of total hip replacement with poly(2-methacryloyloxyethyl phosphorylcholine) -grafted highly cross-linked polyethylene liners: Three-year results of a prospective consecutive series. Mod Rheumatology, 25(2), 286-291 (2015)
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