TRPM4

Is the protein which is called Mera statin -4 (melastatin-4), and TRPM4 (Transient receptor potential cation channel subfamily M member 4, transient receptor potential channel subtype M4) is encoded in gene TRPM4 [¹]; [²]. I emerge on the surface of the cardiac muscle cell and participate in electric activity of the myocardium.

It is known that I control progression of myocardial infarction when I inhibit this channel with a drug [³].

Table of contents

Allied item

• TRPM

Reference materials

1. ^ Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi: 10.1073/pnas.191360198. PMC 58528. It is http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=58528. PMID 11535825 
2. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." Pharmacol. Rev. 57 (4): 427–50. doi: 10.1124/pr.57.4.6. PMID 16382100. 
3. ^ "new technique discovery of the myocardial infarction restraint." Okayama University (July 25, 2013). May 3, 2015 reading.

Allied documents

• Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. pp. 700. ISBN 978-94-007-0264-6. 
• Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization." Cell 109 (3): 397–407. doi: 10.1016/S0092-8674(02) 00719-5. PMID 12015988. 
• Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation." Science 306 (5700): 1374–1377. doi: 10.1126/science.1098845. PMID 15550671. 
• Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role." Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 269–85. doi: 10.1007/978-3-540-34891-7_16. ISBN 978-3-540-34889-4. PMID 17217063. 
• Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). "Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4." Nat Immunol 8 (3): 312–320. doi: 10.1038/ni1441. PMID 17293867. 
• Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). "The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells". Nat Immunol 9 (10): 1148–56. doi: 10.1038/ni.1648. PMC 2956271. It is http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2956271. PMID 18758465 

Outside link

• TRPM4 protein, human - the US National Library of Medicine Medical Subject Headings (MeSH)

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