2016년 11월 26일 토요일

Nontuberculous acid fast bacterium

Nontuberculous acid fast bacterium

It is named tuberculosis mycol. and the cultivable acid fast bacterium except the bacillus of leprosy group generally with) a nontuberculous acid fast bacterium (ひけっかくせいこうさんきん, non-tuberculous mycobacteria; NTM, mycobacteria other than tuberculosis, MOTT) [1] [2]. Was called the non-fixed form acid fast bacterium (atypical mycobacteria) before [2]; [3]. I am distributed in living environment widely [4].

Table of contents

Bacteriological characteristic

Molecular biology develops and can classify it about the genetic property and metabolism of bacteria by DNA and RNA definitely now. However, I was able to ever classify bacteria only by using difference in growth by a nutrient medium, the culture temperature, difference in metabolism of the chemical substance. Therefore a tubercle bacillus and a bacillus of leprosy were typical acid fast bacteria, and other acid fast bacteria were considered to be the special acid fast bacterium which was a non-fixed form. Because it was molecular biologic, and many acid fast bacteria would be classified with technical development, and rather tuberculosis mycol. and bacillus of leprosy group were special bacteria, and it became clear that so-called "non-fixed form acid fast bacterium" had the general property as the acid fast bacterium, I came to be called "a nontuberculous acid fast bacterium".

  • Brook nutrient medium
    When culture it on a brook nutrient medium using a niacin test, color development varies according to the kind of the acid fast bacterium [5]; [6]. The tubercle bacillus uses that a niacin-producing Noh is expensive.

Pathogenic

In the Homo sapiens, either organ of the whole body may be transmitted, but most are the infectious diseases in the lungs when it is not fence-sitting infection practically. The infection power is weak, and it is thought that infection from the soil is important. It is said that there is hardly human → human infection.

When it is the fence-sitting infectious disease in the immunodeficiency state, the disseminated nontuberculous acid-fast bacterial disease with the whole body may develop. In late years the skin nontuberculous acid-fast bacterial disease which is not leprosy is confirmed in Japan (by Mycobacterium marinum, Mycobacterium peregrinum); [7].

Inspection

The culture in the nutrient medium takes time and cannot tell the difference between M. avium and M. intracellulare again, and there is a point inferior to classification ability. However, use inspection using DNA/RNA such as the PCR methods together now because the drug resistance cannot distinguish it when is not culture [8]; [9].

Reference, quotation

  1. ^ "nontuberculous acid-fast bacterial disease." I know the disease: The disease of the lungs and the respiratory tract. Keio University Hospital (March 1, 2010). March 21, 2011 reading.
  2. ^ a b Masakazu Aoki "series firm illness: tuberculosis (10) is reading on p.10, March 21, 2011 in nontuberculous acid-fast bacterial disease (1)" (pdf), "sign of a tuberculous inoculation" 319th, Tuberculosis Association, January, 2008.
  3. ^ Miyoko Endo reads "the infection with nontuberculous acid fast bacterium" on ISSN 0910-5352, March 21, 2011 in "examination of Tokyo microbe information" Vol. 27 second, Tokyo health security research center, February, 2006.
  4. Distribution investigation environment infection Vol.15 (2000) No. 2 P.127-132, doi: of ^ Miki Miyamoto, Yoshio Yamaguchi, Masanori Sasatsu, Legionella genus bacteria in environment and the nontuberculous acid fast bacterium 10.11550/jsei1986.15.127
  5. ^ non-fixed form acid fast bacterium (archive as of August 18, 2009) - Yamamoto laboratory
  6. About ^ niacin test
  7. It is 81-82 ^ Nikkei Medical No. 520.
  8. Acid fast bacterium quickness detection tuberculosis Vol.69 (1994) No. 10 P.593-605, doi: from the clinical specimen with the acid fast bacterium DNA detection kit (amplifier re-core TM mycobacterium) using ^ Masakazu Aoki, Toru Katayama, Fumio Yamagishi others, the PCR method 10.11400/kekkaku1923.69.593
  9. Story (archive as of November 25, 2013) - incorporated administrative agency national hospital mechanism East Tokushima medical center of the ^ respiratory organs internal medicine - acid fast bacterium symptom (tuberculosis and nontuberculous acid-fast bacterial disease)

References

  • Satoshi Mitarai, Akiko Takagi, "nontuberculous acid fast bacterium" clinical inspection Vol.58 (11), 2014/10/30, p.1405-1408, doi: 10.11477/mf.1542200071

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