Isoflavone 7-O- methyl transferase

Isoflavone 7-O- methyl transferase
Identifier
EC number	2.1.1.150
CAS registration number	136,111-54-1
Database
IntEnz	IntEnz view
BRENDA (English version)	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structure	RCSB PDB PDBe PDBj PDBsum
Search PMC articles PubMed articles NCBI proteins

Isoflavone 7-O- methyl transferase (Isoflavone 7-O-methyltransferase, EC 2.1.1.150) is an enzyme catalyzing the following chemical reactions.

S-adenosyl-L-methionine +7 - hydroxy isoflavone${\displaystyle \rightleftharpoons}$S-adenosyl-L-homocysteine +7 - methoxyisoflavone

Therefore, as for the substrate of two of this enzyme, S-adenosyl-L-methionine and 7-hydroxy isoflavone, two products are S-adenosyl-L-homocysteine and 7-methoxy isoflavone.

This enzyme belongs to the family of the methyl transferase letting a transferase particularly 1 carbon group metastasize. The systematic name is S-adenosyl-L-methionine: It is hydroxy isoflavone 7-O- methyl transferase. This enzyme participates in biosynthesis of isoflavonoid.

Source

• Edwards R and Dixon RA (1991). "Isoflavone O-methyltransferase activities in elicitor-treated cell suspension cultures of Medicago sativa." Phytochemistry 30 (8): 2597–2606. doi: 10.1016/0031-9422(91)85107-B. 
• He XZ, Dixon RA (2000). "Genetic manipulation of isoflavone 7-O-methyltransferase enhances biosynthesis of 4'-O-methylated isoflavonoid phytoalexins and disease resistance in alfalfa". Plant. Cell. 12 (9): 1689–702. doi: 10.1105/tpc.12.9.1689. PMC 149079. It is http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149079. PMID 11006341 
• He XZ, Dixon RA (1996). "Affinity chromatography, substrate/product specificity, and amino acid sequence analysis of an isoflavone O-methyltransferase from alfalfa" (Medicago sativa L.). Arch. Biochem. Biophys. 336 (1): 121–9. doi: 10.1006/abbi.1996.0539. PMID 8951042. 
• He XZ, Reddy JT, Dixon RA (1998). "Stress responses in alfalfa (Medicago sativa L). XXII. cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase. Plant. Mol. Biol. 36 (1): 43–54. doi: 10.1023/A: 1005938121453. PMID 9484461. 
• Liu CJ, Dixon RA (2001). "Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis". Plant. Cell. 13 (12): 2643–58. doi: 10.1105/tpc.13.12.2643. PMC 139479. It is http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139479. PMID 11752378 
• Zubieta C, He XZ, Dixon RA, Noel JP (2001). "Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases." Nat. Struct. Biol. 8 (3): 271–9. doi: 10.1038/85029. PMID 11224575. 
• Christensen AB, Gregersen PL, Olsen CE, Collinge DB (1998). "A flavonoid 7-O-methyltransferase is expressed in barley leaves in response to pathogen attack." Plant. Mol. Biol. 36 (2): 219–27. doi: 10.1023/A: 1005985609313. PMID 9484434. 

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