Methylenetetrahydrofolate dehydrogenase (NADP+)

The true title of this article is "methylenetetrahydrofolate dehydrogenase" (NADP+). I change the indication of the title with "methylenetetrahydrofolate dehydrogenase" (NADP+) to break off the limitation of the article name.

Methylenetetrahydrofolate dehydrogenase (NADP+)
Identifier
EC number	1.5.1.5
CAS registration number	9029-14-5
Database
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structure	RCSB PDB PDBe PDBj PDBsum
Gene オントロジー	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Methylenetetrahydrofolate dehydrogenase (NADP⁺)(methylenetetrahydrofolate dehydrogenase (NADP⁺)) Oh, it is an oxidation-reduction enzyme catalyzing the next chemical reaction.

5,10-methylenetetrahydrofolate + NADP⁺ ${\displaystyle \rightleftharpoons}$ 5,10-メテニルテトラヒドロ folic acid + NADPH + H⁺

According to the equation, as for the substrate of this enzyme, 5,10-methylenetetrahydrofolate and NADP⁺, a product are 5,10-メテニルテトラヒドロ folic acid and NADPH and H⁺.

The organization name is 5,10-methylenetetrahydrofolate:NAD^P+ oxidoreductase, and another name has N⁵,N¹⁰-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate:NADP oxidoreductase, 5,10-methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase (NADP).

References

• HATEFI Y, OSBORN MJ, KAY LD, HUENNEKENS FM (1957). "Hydroxymethyl tetrahydrofolic dehydrogenase." J. Biol. Chem. It is 637–47. 227 PMID 13462986. 
• OSBORN MJ, HUENNEKENS FM (1957). "Participation of anhydroleucovorin in the hydroxymethyl tetrahydrofolic dehydrogenase system." Biochim. Biophys. Acta. 26: 646–7. doi: 10.1016/0006-3002(57) 90,117-8. PMID 13499428. 
• RAMASASTRI BV, BLAKLEY RL (1962). "5,10-Methylenetetrahydrofolic dehydrogenase from bakers' yeast. I Partial purification and some properties." J. Biol. Chem. It is 1982–8. 237 PMID 14490085. 
• Yeh YC, Greenberg DM (1965). "Purification and properties of N5, N10-Methylenetetra-hydrofolate dehydrogenase of calf thymus." Biochim. Biophys. Acta. It is 279–91. 105 PMID 4379024. 

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