ホスミドマイシン
 | |
| Material name by the IUPAC glossology | |
|---|---|
| 3-[Formyl(hydroxy)amino]propylphosphonic acid | |
| Identification | |
| CAS number (MeSH) | 66,508-53-0 |
| ATC cord | Unavailable |
| PubChem | CID: 572 |
| DrugBank | EXPT01469 |
| ChemSpider | 555 |
| UNII | 5829E3D9I9 |
| ChEBI | CHEBI: 443725 |
| ChEMBL | CHEMBL203125 |
| Chemical data | |
| Chemical formula | C4H10NO5P |
| Molecular weight | 183.100 g/mol |
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| |
ホスミドマイシン (fosmidomycin) is one of the antibiotics isolated from the culture fluid of ストレプトミケス genus bacteria [1]. I specifically inhibit isoprenoid biosynthetic DXP レダクトイソメラーゼ which is non-a key to mevalonate course enzyme. The Ki level is 99 nM for 80 nM, franc Sisera genus (Francisella) enzyme for 38 nM, tubercle bacillus enzyme for E. coli enzyme [2].
The discovery of the fault mevalonate course in the Falciparum shows that I can use ホスミドマイシン and other repressors as antimalarial [3]. Combination therapy with clindamycin for malarial treatment is examined, and ホスミドマイシン wants to really gain a favorable result [4]; [5] [6]. In falciparum malaria parasite () (Plasmodium falciparum), it is shown that the increase of the copy number of the target enzyme (DXP レダクトイソメラーゼ) relates to in vitro ホスミドマイシン tolerance [7].
Footnote
- ^ Iguchi, E; Okuhara, M, Kohsaka, M, Aoki, H, Imanaka, H (1980). "Studies on new phosphonic acid antibiotics. II. Taxonomic studies on producing organisms of the phosphonic acid and related compounds.". The Journal of antibiotics 33 (1): 19–23. It is . PMID 7372546
- ^ Jawaid, S., Seidle, H., Zhou W, Abdirahman, H., Abadeer, M, Hix, JH, van Hoek, ML and RD Couch. "Kinetic Characterization and Phosphoregulation of the Francisella tularensis 1-Deoxy-D-Xylulose 5-Phosphoate Reductoisomerase" (MEP Synthase). PLOS One 4 (12): e8288. doi: 10.1371/journal.pone.0008288. PMID 20011597.
- ^ Jomaa, H; et al. (1999). "Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs." Science 285 (5433): 1573–6. doi: 10.1126/science.285.5433.1573. PMID 10477522.
- ^ Borrmann, S; et al. (2004). "Fosmidomycin-clindamycin for Plasmodium falciparum infections in African children." J Infect Dis 189 (5): 901–8. doi: 10.1086/381785. PMID 14976608.
- ^ Borrmann, S; et al. (2006). "Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria". Antimicrob Agents Chemother 50 (8): 2713–8. doi: 10.1128/AAC.00392-06. PMC 1538678. It is . PMID 16870763
- ^ Ruangweerayut, R; et al. (2008). "Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria". Malaria J 7 (1): 225. doi: 10.1186/1475-2875-7-225. PMC 2600645. It is . PMID 18973702
- ^ Dharia, NV; et al. (2009). "Use of high-density tiling microarrays to globally identify mutations and elucidate mechanisms of drug resistance in Plasmodium falciparum". Genome Biology 10 (2): R21. doi: 10.1186/gb-2009-10-2-r21. PMC 2688282. It is . PMID 19216790
This article is taken from the Japanese Wikipedia ホスミドマイシン
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