2016년 4월 25일 월요일

O-demethyl puromycin-O-methyl transferase

O-demethyl puromycin-O-methyl transferase

O-demethyl puromycin-O-methyl transferase
Identifier
EC number 2.1.1.38
CAS registration number 37,257-04-8
Database
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structure RCSB PDB PDBe PDBj PDBsum
Gene オントロジー AmiGO / EGO

O-demethyl puromycin-O-methyl transferase (O-demethylpuromycin O-methyltransferase, EC 2.1.1.38) is an enzyme catalyzing the following chemical reactions.

S-adenosyl-L-methionine + O- demethyl puromycin \rightleftharpoonsS- adenosyl-L-homocysteine + puromycin

Therefore, as for the substrate of two of this enzyme, S-adenosyl-L-methionine and O-demethyl puromycin, two products are S-adenosyl-L-homocysteine and puromycin.

This enzyme belongs to the family of the methyl transferase letting a transferase particularly 1 carbon group metastasize. The systematic name is S-adenosyl-L-methionine: It is O-demethyl puromycin O- methyl transferase (S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase). This enzyme participates in puromycin biosynthesis.

Source

  • Rao MM, Rebello PF, Pogell BM (1969). "Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin." J. Biol. Chem. 244 (1): 112–8. PMID 5773275. 

This article is taken from the Japanese Wikipedia O-demethyl puromycin-O-methyl transferase

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