Fluticasone
 | |
| Material name by the IUPAC glossology | |
|---|---|
| 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17- (1-oxopropoxy) -androsta-1,4-diene-17-carbothioic acid (6 α, 11 β, 16 α, 17 α) - S-(fluoromethyl) ester | |
| Clinical data | |
| Fetus degree of risk classification |
|
| Legal regulation |
|
| Dosage method | Inhalation, intranasal; transdermal (ointment, cream) |
| Pharmacokinetics data | |
| Bioavailability | 0.51% (intranasal administration) |
| Plasma protein combination | 91% |
| Metabolism | Intranasal - liver CYP3A4 |
| Half-life | Ten hours |
| Excretion | Kidney |
| Identification | |
| CAS number | 80,474-14-2 |
| ATC cord | topical, R01AD08 nasal, R03BA05inhaled |
| PubChem | CID: 444036 |
| DrugBank | APRD00065 |
| KEGG | D07981 |
| Chemical data | |
| Chemical formula | C25H31F3O5S |
| Molecular weight | 500.572 g/mol |
Fluticasone (fluticasone) is a kind of the corticosteroid agent. I am used for treatment such as bronchial asthma or allergic rhinitis mainly.
Bronchial asthma
GlaxoSmithKline is a brand name called the Furuta id in Japan and sells a combination agent with the bronchodilator salmeterol Naho Kishi acid salt to bronchial asthma with a brand name of the ad air with the inhalant which assumes fluticasone propionate (abbreviated designation FP) an ingredient again. GlaxoSmithKline releases レルベア based on furancarboxylic acid fluticasone afterwards [1]. As for the franc carboxylate ester, effect lasts than the propionate ester mentioned above, and it is characterized by an effect being provided by one absorption a day.
In addition, from doctor medicine manufacture, aerosol vapor フルティフォーム which is medical mixture of fluticasone propionate and ホルモテロール is released. The feature of this is that it is pMDI preparation, but, as a general rule, the inhalation divides it into twice a day and is necessary.
Because the inhalational steroid medicine does not have an immediate effect, I use it for the purpose of not being to suppress the symptom of the immediate nature period of the bronchial asthma, and preventing acute attack and aggravation of the bronchial asthma in what I inhale regularly every day.
Summary
Step 2 (mild sustained model asthma) is the above as management medicine and, in asthmatic prevention, management guidelines (2006) by Japanese Society of Allergology, is recommended as a first-line drug every day. Erethism increases, and, as for the bronchial asthma, an attack becomes easy to be caused by inflammation being taking place in the respiratory tract and causes the remodeling when inflammation continues again. For example, the wound becomes sensitive to little stimulation, and a scab comes off many times again and is the same as what the part thickens when a scab repeats the state that there is again. It suppresses inflammation in this way, and it is an inhalational steroid to prevent remodeling.
Effect, effect
Bronchial asthma
Use, dose
An adult is usually given 100 μg of once inhalationally twice a day. In addition, I increase and decrease by a symptom appropriately, but the maximum dose of 1st assumes 800 μg a limit.
An infant is usually given 50 μg of once inhalationally twice a day. In addition, I increase and decrease by a symptom appropriately, but the maximum dose of 1st assumes 200 μg a limit.
Matters that require attention
The Furuta id is the inhalational steroid medicine which I can use safely for a long term, but it is necessary to gargle after the inhalation to prevent a local side effect (a husky voice and oral candida).
In addition, you should check the adrenal cortex function when it is necessary to use a high dose for a long term. (because it is thought, adrenocortical insufficiency inspects an adrenal cortex function after during weight loss of the systemic steroid and the secession in the patients receiving long-term or a large quantity of systemic steroids therapy, and pay enough attention to the aggressions such as an injury, an operation, the serious case infectious disease, and increase the temporarily, if necessary, again systemic steroid in quantity.[2])
Nasal inflammation
GlaxoSmithKline is a brand name of Flunase in Japan, and several companies sell a nasal drop based on the fluticasone propionate to allergic rhinitis with the brand names such as キリガミール, ska irone, F bifull Chika nose, プロチカゾン, フロラーズ, the millimeters caret as the generic drug again.
In 2009, GlaxoSmithKline released a nasal drop based on furancarboxylic acid fluticasone with the brand name of the Arami strike like レルベア mentioned above and started [3]. The feature is that this is effective at once a day unlike Flunase that the dosage is necessary twice a day.
The fluticasone nasal drop is effective against "sneezing, mucus, the stuffy nose" that is three major symptoms of the nasal inflammation equally.
Effect, effect
Allergic rhinitis, vasomotor nasal inflammation
Footnote, source
- ^ レルベア, GlaxoSmithKline
- ^ Furuta id discus attached document information September, 2009 revision (the tenth edition)
- ^ [new medicine] fluticasone franc carboxylate ester Arami strike: Steroid medicine for the once a day model nose mist of the second drug、Nikkei Medical、2009June 12、2014June 2Reading
Allied item
- A combination agent with salmeterol fluticasone - salmeterol xinafoate.
- Triamcinolone
This article is taken from the Japanese Wikipedia Fluticasone
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