Titer

The titer (the りきか United States: titer, titre) is one of the assays of the density (activity) in the biology.

Table of contents

Summary

The titer (the titer United States: titer British: titre) is one of the assays of the density of specimen in the biology (activity). ^[1][²] [³]

A titer examination is to combine a positive /-negative evaluation with serial dilution and is technique to perform concentration measurement. In other words, I make the dilution series of specimen, and a positive /-negative evaluation does it with titer with the dilution (density is the lowest, and, in other words, a dilution coefficient is the highest) of the limit becoming positive. ^[4] It is a concept equivalent to the specific activity in case of protein and the enzyme. An example of the titer includes virus value, antibody titer (the concept that the antibody titer is different from the antibody valence).

For example, the positive measurements become 1:256 titer by eight phases of first double dilution. (i.e., 2^-8) [⁵] 

Example of the titer

Virus value

The titer (virus value, viral titer) of the virus is the minimum density so that viruses (the liquid which a virus is included in) infect a cell among specimens (the best dilution magnification).

For example, it is measured in the following procedures.

• Dilution: I make the serial dilution series of specimen.
• Infection: I transmit wash each to cells with sensitivity (the virus can be transmitted) to a target virus.
• An evaluation: I confirm whether wash each is infected.

The titer of the virus depends on the kinds such as cells to transmit and the evaluation method. I can measure a near thing by virus density itself by the PCR methods, but big things and small things can be different by a method recently even if it is the same titer without it being to influence the affinity with a cell and the evaluation method to transmit it in titer to be the necessarily same as other assays.

See also

• W/v
• Mg%
• Virus fixed-quantity

References

1. ^ Michael G. Kaplitt; Arthur D. Loewy (1 August 1995). Viral vectors: gene therapy and neuroscience applications. Academic Press. pp. 304. ISBN 978-0-12-397570-6. http://books.google.com/books?id=bKqy7YvJpoIC&pg=PA304 March 18, 2012 reading. . 
2. ^ Yasuo Oshima, others, "Biochemistry dictionary" Tokyo chemistry coterie, The fourth edition (2007/12/10) P1429
3. ^ Japanese PharmacopoeiaThe 14th edition[1]20. Microbiologic titer docimasy [2] of the antibiotic
4. ^ Morag Crichton Timbury (1994). Notes on medical virology. Churchill Livingstone. p. 27. ISBN 978-0-443-04872-2. http://books.google.com/books?id=4ZNrAAAAMAAJ March 18, 2012 reading. . 
5. ^ Harold E. Fox; Jessica Bienstock (21 December 2010). The Johns Hopkins Manual of Gynecology and Obstetrics. Lippincott Williams & Wilkins. pp. 226. It is reading ISBN 978-1 - 60,547-433-5 on http://books.google.com/books?id=4Sg5sXyiBvkC&pg=PR226 March 18, 2012. . 

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