EMDOGAIN
The periodontium reproduction instruction materials that EMDOGAIN (Emdogain®) is composed primarily of enamel matrix derivative released by viola company (the Biora AB head office: from Sweden Malmo City, 2003 a subsidiary of of Swiss straw man (Straumann)).
In Swedish Karolinska Institute, I was developed by Dr.Hammarstrom and others of the founder of viola company. The authorization of Ministry of Health, Labour and Welfare is granted in Japan in 1998, and the EMDOGAIN gel which is an improved version is authorized in 2002. It was treatment of the free medical treatment that principle health insurance did not cover, but was appointed for advanced medical care in 2007.
Table of contents
Summary
The conventional treatment in periodontal disease removed the causative agent which let you cause inflammation such as calculus, necrotic cement and was the thing which promoted healing, but the reproduction of the periodontium which was already destroyed was difficult. EMDOGAIN plans reproduction such as destroyed cement by applying it after treatment of the tooth lap surgery.
Action mechanism
The enamel matrix protein is able to guide hard tissue to no cellularity.
At the time of development of tooth, the enamel matrix protein secreted by an epithelium sheath of ヘルトヴィッヒ acts on the undifferentiated mesenchymal tissue in the periodontal membrane and I let cementoblast differentiate and create structurelessness-related cement. EMDOGAIN is a drug based on the enamel matrix protein extracted than the dental germ of the feebleness pig and expects that the undifferentiated mesenchymal tissue in the periodontal membrane differentiates to cementoblast like the above by applying it after treatment of the tooth lap surgery, and acellular cement regenerates it.
A similar cure includes the GTR method, but, as for the GTR method, as for cement which there is for a cure performing space making, it is existence cellular cement, and the adhesive power with the dentin is weaker than EMDOGAIN of the acellular cement.
EMDOGAIN and EMDOGAIN gel
The thing which improved EMDOGAIN is EMDOGAIN gel (in neither a brand name). "EMDOGAIN" was a main ingredient and two drugs constitution of the dissolution liquid, but "the EMDOGAIN gel" filled a syringe with a mixture (a main ingredient and dissolution liquid) beforehand, and improvement of the operability is planned in comparison with conventional products. In addition, EMDOGAIN was an unheated blood product, but the EMDOGAIN gel becomes the heated blood product.
Allied item
This article is taken from the Japanese Wikipedia EMDOGAIN
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