Piperacillin tazobactam
| List of ingredients | |
|---|---|
| Piperacillin | Ureidopenicillin antibiotic |
| Tazobactam | Beta-lactamase inhibitor |
| Clinical data | |
| Drugs.com | monograph |
| MedlinePlus | a694003 |
| Fetus degree of risk classification |
|
| Legal regulation |
|
| Dosage method | The transvenous dosage |
| Identification | |
| CAS number (MeSH) | 123,683-33-0  |
| ATC cord | J01CR05 (WHO) |
| PubChem | CID: 9918881 |
| ChemSpider | 8094523  |
| ChEMBL | CHEMBL436129 |
Piperacillin tazobactam is medical mixture of penicillin derivative piperacillin and beta lactamase repressor tazobactam of the wide area spectrum. The product name is Japan; "ゾシン" "タゾシン" (TAIHO Phamaceutical Co., Ltd. production sale), "Tazocin" (sell Pfizer production in Canada, U.K., Ireland, Australia, New Zealand, Italy), "Zosyn" (the United States, Pfizer production sale). The combination of these drugs shows an effect for many Gram positive bacteria and a Gram negative bacterium, Pseudomonas aeruginosa.
Table of contents
Use
The main use is intensive care medicine (including pneumonia, the peritonitis), a diabetes-related lower limbs infectious disease, a pyrogenic neutropenia (e.g.,: after chemotherapy). I usually give this drug from a vein in 3-30 minutes for 6 or every 8 hours. I run more than four hours and can give it continuously. It is thought that blood concentration maximizes time more than the smallest stunt density (MIC) as for the dosage for a long time.
Piperacillin tazobactam is considered to be a first-line drug of bacteremia, sepsis of the cancer patient with the neutropenia by NIH. [1]
Indication
- General infectious disease
- Adaptation species of bacteria: To this agent Staphylococcus Rosenbach with the sensitivity, the streptococcus genus, Streptococcus pneumoniae, the enterococcus genus, Moraxella (Branhamella), catarrhalis, Escherichia coli, the シトロバクター genus, Klebsiella, Enterobacter, Serratia, the Proteus genus, the professional biden Shea genus, Haemophilus influenzae, Pseudomonas aeruginosa, Acinetobacter, Peptostreptococcus, Clostridium (except the Clostridium difficile), Bacteroides, the プレボテラ genus
- Indication: Sepsis, pneumonia, pyelonephritis, complexity cystitis, peritonitis, abscess, cholecystitis, cholangitis in the abdominal cavity
- Pyrogenic neutropenia
Side effect
The most frequent side effect is loose bowels (7% - 11%). [2] Clostridium difficile-related loose bowels were seen in 4.9% in a certain study. [3] Platelet function restraint and thrombocytopenia are reported. [4]
Product name
"ゾシン" "タゾシン" is sold as a starting article in Japan. Other than Tazocin and Zosyn, Biopiper TZ, Brodactam, Piptaz, Maxitaz, Kilbac, Trezora, Du-Tazop, Tazopen, Sytaz, Inzalin TZ are sold.
Footnote
- ^ "Neutropenic Sepsis: Prevention and Management of Neutropenic Sepsis in Cancer Patients - National Library of Medicine - PubMed Health." 20170331 reading.
- ^ "Piperacillin and Tazobactam Sodium". Merck Manual Professional. It archives it than an original as of November 20, 2010. 20170331 reading.
- ^ Yeung, EYH (2012). "A Retrospective Analysis of the Incidence of Clostridium Difficile Associated Diarrhea with Meropenem and Piperacillin-tazobactam". International Journal of Collaborative Research on Internal Medicine & Public Health 4 (8): 1567–1576.
- ^ Recurrent acute thrombocytopenia in the hospitalized patient: Sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia. 85. (January 2010). pp. 71–74. doi: 10.1002/ajh.21536. PMC 4410979. It is . PMID 19802882
This article is taken from the Japanese Wikipedia Piperacillin tazobactam
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