Glioblastoma
| Data of the glioblastoma | |
| ICD-10 | C719 |
| Statistics | The source: |
| The world number of patients | Half size number, three columns of ends person (20xx age xx moon xx day) |
| The number of patients of Japan | Half size number, three columns of ends person (20xx age xx moon xx day) |
| ○○Society | |
| Japan | Japanese neurosurgical society |
| The world | AANS & CNS Neurosurgery On-Call |
| This article uses the model of the Wiki project | |
The glioblastoma (こうがしゅ British: glioblastoma) is a kind of the brain tumor. I am considered to be malignant tumor in a glioma (glioma).
Table of contents
Definition (concept)
In a malignant tumor derived from a glial cell (mainly macroglia), I point to the thing which is extremely undifferentiated, and has high increase ability. Tumor is often accompanied by bleeding, and the inside necrotic nest of tumor may be seen. The neoplastic cell is circular, and various shapes such as the spindle shape exist, and big things and small things are nonequivalent.
Condition of a patient
Progress is extremely fast by the increase of rapid tumor. It is seen that a symptom turns worse by a unit for several weeks.
Epidemiology
It is 45-79 years old, and the predilection age occurs in middle age or later frequently. There are slightly more men (1.4 times). I occupy approximately 9.0% of primary brain tumors. The frontal lobe has most it followed by appears most commonly on temporal lobe, parietal lobe.
Symptom
The intracranial hypertension symptom due to tumor increasing rapidly is seen. The first symptom has many headaches. As well as other brain tumors, there is many that a strong headache is seen in morning (morning headache). In addition, the exercise paralysis, convulsions, a drop of the orientation are seen.
Inspection
- CT
- A high absorption range, the neighboring necrotic parts and cysts are contrasted tumor substance in the simple CT as low-attenuation foci. Tumor substance is reinforced in the contrasting CT using contrast media heterogeneously.
- MRI
- As for tumor, a tumor and the neighboring brain edema become the hyperintense area with low signal area, the T2-weighted image with the T1 emphasis image a little. The tumor inside reflects necrosis, and low ... hyperintense area often becomes the image which mingled while the border of tumor becomes the hyperintense area by the contrasting MRI using gadolinium. I name these views ring enhancement. In addition, as for the ring enhancement, a brain abscess, a metastatic brain tumor are often finished as differentiation not the views that are specific for a glioblastoma.
Diagnosis
I doubt a brain tumor from clinical manifestations and definitively diagnose a result of CT and the MRI for the cause.
Treatment
There is not the method to cure radically for this tumor. Every possible extraction by the operation is basic, but all knobs are usually impossible because tumor is invasive, and the border with the normal organization is indistinct. Therefore combination with the postoperative radiotherapy and chemotherapy becomes basic. It is common now that the chemotherapy uses temozolomide.
Convalescence
It is contained in the worst class in comparison with all malignant tumors in the brain tumor most badly. As for the survival rate, as for the survival rate, a survival rate is 7.8% for 13.1%, five years for 51.6%, three years for one year. In addition, most of the remote metastasis does not do the glioblastoma and have characteristic that it is a chisel in the brains that metastasize.
Clinical department
References
- The standard neurosurgery tenth edition, medical study
This article is taken from the Japanese Wikipedia Glioblastoma
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