Acetylsalicylic acid deacetylase
| Acetylsalicylic acid deacetylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifier | |||||||||
| EC number | 3.1.1.55 | ||||||||
| CAS registration number | 87,348-04-7 | ||||||||
| Database | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA () | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structure | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Gene オントロジー | AmiGO / EGO | ||||||||
| |||||||||
Acetylsalicylic acid deacetylase (Acetylsalicylate deacetylase, EC 3.1.1.55) is an enzyme catalyzing the following chemical reactions.
- Acetylsalicylic acid + waterSalicylic acid + acetate
Therefore, as for the substrate, two, the product of acetylsalicylic acid and the water are salicylic acid and two of the acetate.
These enzymes are classified in a hydrolase and act on ester bond in particular. The systematic name is acetylsalicylic acid O- acetyl hydrolase (acetylsalicylate O-acetylhydrolase). I am called the aspirin esterase (aspirin esterase).
Source
- Ali B, Kaur S (1983). "Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases." J. Pharmacol. Exp. Ther. 226 (2): 589–94. PMID 6875867.
- Kim DH, Yang YS, Jakoby WB (1990). "Aspirin hydrolyzing esterases from rat liver cytosol." Biochem. Pharmacol. 40 (3): 481–7. doi: 10.1016/0006-2952(90)90546-W. PMID 2383281.
- White KN, Hope DB (1984). "Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver." Biochim. Biophys. Acta. 785 (3): 138–47. doi: 10.1016/0167-4838(84) 90,138-9. PMID 6704404.
This article is taken from the Japanese Wikipedia Acetylsalicylic acid deacetylase
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