2017년 4월 5일 수요일

6-hydroxy nicotinic acid dehydrogenase

6-hydroxy nicotinic acid dehydrogenase

6-hydroxy nicotinic acid dehydrogenase
Identifier
EC number 1.17.3.3
Database
IntEnz IntEnz view
BRENDA (English version) BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structure RCSB PDB PDBe PDBj PDBsum
Gene オントロジー AmiGO / EGO

6-hydroxy nicotinic acid dehydrogenase (6-hydroxynicotinate dehydrogenase) is an oxidation-reduction enzyme catalyzing the next chemical reaction in one of the nicotinic acid and the nicotinamide metabolism enzymes.

6-hydroxy nicotinic acid + H2O + O2 2,6-dihydroxy nicotinic acid + H2O2

As for the substrate of this enzyme, the product is 2,6-dihydroxy nicotinic acid and H2O2 in 6-hydroxy nicotinic acid, H2O and O2.

This enzyme belongs to an oxidation-reduction enzyme and specifically acts on a CH group or a CH2 group as a receptor in O2. The organization name is 6-hydroxynicotinate:O2 oxidoreductase, and another name has 6-hydroxynicotinic acid hydroxylase, 6-hydroxynicotinic acid dehydrogenase, 6-hydroxynicotinate hydroxylase.

References

  • Nagel M and Andreesen JR (1989). "Molybdenum-dependent degradation of nicotinic acid by Bacillus sp DSM 2923." FEMS Microbiol. Lett. 59: 147–152. doi: 10.1111/j.1574-6968.1989.tb03099.x. 
  • Nagel M and Andreesen JR (1990). "Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini." Arch. Microbiol. It is 605–613. 154 

This article is taken from the Japanese Wikipedia 6-hydroxy nicotinic acid dehydrogenase

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