Lysophosphatidic acid

Lysophosphatidic acid
IUPAC name (Z)-9-オクタデケン acid (2-hydroxy-3-ホスホノオキシプロピル)
Another name LPA
Identification information
CAS registration number	22,002-87-5
PubChem	5497152
MeSH	lysophosphatidic+acid
SMILES CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(=O)(O)O)O
Characteristic
Chemical formula	C21H41O7P
Molar mass	436.52 g/mol
I can put a case, the data without the special mention for normal temperature (25 degrees Celsius), the ordinary pressure (100 kPa).

Lysophosphatidic acid (Lysophosphatidic acid, LPA) is a phosphatide derivative working as signaling molecules and is a phosphatidate synthetic intermediate product. The biosynthesis has some potential roots, but what is characterized best depends on lysophospholipase D called automatic taxine and removes Colin from lysophosphatidylcholine.

LPA acts as mitogen for activation of three high affinity G protein conjugate receptors called LPA1, LPA2 and LPA3 (or EDG2, EDG4 and EDG7). In addition, LPA4 (p2y9/GPR23), LPA5 (GPR92) and LPA6 (GPR87) were confirmed as LPA receptor recently.

The abnormal LPA signaling links to a cancer by many courses to stimulate cell proliferation. The abnormal adjustment of automatic taxine or the LPA receptor derives hyperproliferation to contribute to neoplasia and metastasis.

References

• Moolenar, W.H., Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger. J. Biol. Chem. 1995. (270)22:12,949. Article.
• Mills, G.B., Moolenaar, W.H., The Emerging role of lysophosphatidic acid in cancer. Nat. Rev. Cancer. 2003. (8): 582. Article

Allied item

• Automatic taxine
• Phosphatidic acid
• Lysophosphatidic acid receptor

This item is an unfinished item in conjunction with the chemistry. I demand the cooperator who corrects it, and corrects this item (a project: chemistry /Portal: chemistry).

It is acquired by "https://ja.wikipedia.org/w/index.php?title= lysophosphatidic acid &oldid=48504190"

This article is taken from the Japanese Wikipedia Lysophosphatidic acid

This article is distributed by cc-by-sa or GFDL license in accordance with the provisions of Wikipedia.

Wikipedia and Tranpedia does not guarantee the accuracy of this document. See our disclaimer for more information.

In addition, Tranpedia is simply not responsible for any show is only by translating the writings of foreign licenses that are compatible with CC-BY-SA license information.