There was what was confused with Russ Freeman (RAS Freeman, the real name: Russell Donald Freeman) of the West Coast jazzpianist of the identical notation for a while, and all music guides woke up confusion at the net tops when the pianist died in June, 2002.
It is close to Kenny G and David Benois who participated in Moonlighting and makes the unit of the the ベノワ Freeman project with Benois and announces The Benoit/Freeman Project2 (the title in Japanese: ストラッティン, a peak record) in title, The Benoit/Freeman Project (the title in Japanese: Mirage, GRP) in 2004 in 1994.
I participate in album NATURAL of T-SQUARE of the announcement as a producer in 1990.
It is belonging to solo and announces Christmas album Holiday (GRP) in 1995. I install a self-label peak record with Andy Howard of the manager in GRP in 1996 and become independent in Rypien ton organization tenth year and 1997 to be and move to Windham leech record affiliated with BMG. I announced coproduct From the Redwoods to the Rockies with Craig チャキーコ of the guitarist in this label and contracting 1999.
Program a keyboard, a base, a drum as well as a guitar with the album; many parts including the mixture self-; often produce it.
The guitar play plays the phrase which is jazz + lock affected by Larry Carlton, Lee Ritenour very smoothly. On the other hand, I receive the influence of Jimi Hendrix and may play an American national anthem in solo live.
As for the early days, a variety of in a guitar synthesizer. As well as the unison with the guitar, it is played in a solo part. Current Maine is Brian Moore.
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The girl who uses the skill of the quick draw of the sword to appear than "sinter blooming on fencer - moon of the second wave abusive curtain moonshine by the late Tokugawa period, flower ... which is scattered, and goes." Soon after having hit sword "八十枉津日太刀" of the moment, the father, high peak source storehouse which is a swordsmith falls illness and, therefore, holds strong loathsomeness for a moment. But I go for a trip to meet in a moment while being at a loss.
It is usually character gentle at heart not to like fights. However, I change into a cool-headed executioner when I repeat 斬殺 by a CPU war (or an interpersonal war), and lines and the ending at the time of the victory change to the thing corresponding to it, too.
I am looking for the whereabouts of the moment by the will of the source storehouse on the story, but both are not concerned on the game directly. 天野漂 where a boss is an acquaintance of the source storehouse comes up in fixation.
By "CAPCOM VS. SNK 2 MILLIONAIRE FIGHTING 2001" (following "CVS2" and notation) of CAPCOM development and sales, it was adopted from the character of "the fencer of the moonshine" alone. Things similar to that of Tachibana Ukyo of the quick draw of the sword messenger appearing for the "samurai spirits" series are usually seen in a part of the skill on this occasion.
Characteristic in the game
There is much skill that outbreak is fastness, and relatively has a long reach, but the chance is very big because there is movement to perform of 納刀. There is much skill that receives a counterattack even if I let a partner make a hit depending on a matter of course, a moment when I miss a ball.
There is the thing which the art changes into by a moment, and "a last-minute chance not to receive a counterattack" is required more than other characters.
In addition, some time in for the skill and the special skill are usually long, and "I stand and play it" of the sound is high-performance.
Commentary of the skill
The feature is that I am assigned all to the last of 技名 of the sound with "... 也".
Throw
也 to make use of naturally
I fly away a partner by a motion such as the aikido.
也 to cut it, and to hide
"CVS2" The throw that it was added で to. After catching a partner, and hitting the elbow, and having done it, I am used to cut it twice.
I the special skill
事肝要也 which does not forget to stop it
"Moonshine" にのみ exists; chase down; the skill. I stick a sword into the partner who fell down.
也 which takes the disguised withdrawing
"CVS2" The の special skill. I swing down the sword which a short distance rises and raised in strong P. Wide swing cancellation is possible.
Art (finisher)
也 to cut in Toma
I more greatly step and do an unsheathed sword and I stretch it out at the full blast and usually cut it. Reach is long, but a chance is big and receives a counterattack when I let you make a hit in weak を short distance. I take down in strong だと lower berth judgment, but a chance is bigger, and any chance receives a counterattack if guarded.
也 which cuts 近寄 りて
The skill to be used to rush for a partner, and to cut it. A chance after power and the skill varies according to the distance with the partner. I change for the skill to cut in cross-purposes state at the time of the coherence and damage becomes heavy and I cancel it and can connect it with the different skill (I include sublimation).
也 which points out confronting each other
The skill to point out the pit of the stomach of the partner in the sheath of the sword. Middle section judgment. I can pursue it by the specific skill.
也 to match a residence with
The pro-so-called knockout blow to take the upper section and the attack of the middle section, and to throw a partner to the air by movement such as 合気 skill. Because there is "a flip", I am not used very much, but I cancel an attack and can start it.
"Moonshine" Then it was possible and can pursue the pursuit only by the exclusive skill freely because stiffening is removed after having been selected in "CVS2".
也 which cuts 抜 かば
Exclusive 追撃技 which is derived from "也 to match a residence" with. I am used to cut a partner with a sword. The phenomenon that power rises to when I hit it just before the partner who dropped makes a landing is caused.
也 not to cut if I do not outrun you
Exclusive 追撃技 which is derived from "也 to match a residence" with. I hit a partner with the sheath of the sword. A fainting level to stun a partner is high.
也 to dodge in a hair's breadth
Lean back in the upper bodies; make a move. So-called; avoid it, and is movement, but it is rare that is used to avoid an attack because an unrivaled range is small, and "a spring device" exists, and to be able to hold it.
It is 詰 めること 肝要也 at an interval
The exclusive skill to be derived from "也 to dodge in a hair's breadth." I dash towards front. I can pass through a partner. Cancellation is possible by a finisher.
Interval をおくこと 肝要也
The exclusive skill to be derived from "也 to dodge in a hair's breadth." I go back backward and step. I can take out a jump attack and a spring device the other day. I can sublimate at the time of a landing.
心也 which does not neglect the preparation
The skill to save a quality of sword gauge by turning the back on a partner, and praying. I save a gauge in S-GROOVE by the skill to shift from a provocation by "moonshine" in "CVS2", and movement is similar to this.
Super art (super finisher)
神気也 which does 発勝
発展技 of "也 cutting 近寄 りて." I am used to rush at high speed, and to cut a partner in cross-purposes state. A sound finishes rushing and puts a sword in the sheath, and blood finally breaks out from a wound.
Potentiality art
心也 which is not afraid of death
Art of super-high-speed unsheathed sword that performance changes by a moment. It becomes the blow that I cannot guard to be proud of the best power to in the skill of the sound when I approach it with a partner.
When a ripple to occur from the step makes a hit, a flash of light such as the thunder runs, and each other stands still for several seconds, and blood begins to blow from the body of the partner in large quantities at the same time as 納刀 is over.
When there is a partner outside a moment, I turn into 遠距離打撃技 hitting the shock wave.
Because I am handled as a blow, both can play it not an arm throw.
"CVS2" Then I am strange without a quick draw of the sword to hit at zero distance. A chance is narrow, but almost boasts of power great by just that much so as not to prove right directly when coherence is not in a state. An exclusive victory pose when I gave the decisive blow by this skill exists.
Boisterous dance art
也 which goes ahead of a corpse
After having rushed, I dance boisterously and attack it. Contents change by additional input. A type standard as for the type as well as a maple and an Article 1 light. I use it as MAX super finisher like "心也 which is not afraid of death" in "CVS2".
I visit the source storehouse of the old friend to have you defeat love sword "man's looks" again. A special conversation demonstration is inserted before play in addition with the moment mentioned above.
In the ED at "the neo-geo-battle Colosseum", the swordsmith who seems to be a source storehouse gets nervous in a topic by the conversation with the harlot. Of course it may be said that it is the work that the crossover can make because it is different from "a samurai spirits" in times setting.
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Gargano is born in OhioCleveland on August 14, 1987. I enter the ring with permission of the J.T. lighting that is an owner of the Cleveland oar professional wrestling (Cleveland All-Pro Wrestling / CAPW) at the age of 8 years old. During Saint Edward Senior High School attendance at school, I enter the wrestling school of CAPW in order to become a professional wrestler. I start training by J.T. lighting of CAPW and the cause of Josh プロフィビション at the age of 16 years old. I make my debut at a ring of the Cleveland oar professional wrestling in 2005. I get CAPW youth heavyweight class throne in October, 2006. I continue participating for a while and I farewell Alex sherry and the tag of the Chris say bottle in partnership with Josh プロフィビション in August, 2007 and play a game and leave CAPW afterwards.
Absolute Intense Wrestling (2006-2016)
It is participated in the war in February, 2006 by absolute in tense wrestling (Absolute Intense Wrestling) based in the Cleland. I achieve the first ever victory from Tyrone Evans (Michael ターヴァー of former WWE) for the end of April though a straight defeat lasts three at first. I try the AIW in tense D vision throne that the Tyler black lasts in March, 2008 for the first time. I was not able to obtain throne in draw for 15 minutes, but I challenge it again in May and get throne. I return it under the influence of an injury in November though I defend throne for half a year. I participate in a tournament of the in tense D vision in February, 2009 and I win against Jimmy DeMarco and win a title again. I continued maintaining it until I was robbed of it by Josh プロフィビション in May.
Gargano comes to take flip ケンドリック and the aeroform (Aeroform) and action of Lewis Lyndon in April, 2010. I participate in a tournament by the team with the aeroform and participate in 2010 King of Trios tournament of the power as a representative of AIW as championship, the right that won the championship. I participate in プロフィビジョン, sterling James Keenan, 4way match of Tommy Mercer in June and acquire the AIW absolute throne which is the belt of the AIW single highest peak. I bet Brian Daniel loss and a title at the night when I acquired it and defend it by play, a draw. I continued holding a title until I was defeated by Cima Zion in June, 2011 and lost a title. I participated in 30 rumbles in March, 2012 and broke Tim Don strike and had the challenge right to the AIW absolute throne which lasted of Cima in my hand.
Pro Wrestling Ohio / Prime Wrestling (2007-2013)
I appear in professional wrestling Ohio (Pro Wrestling Ohio) in November, 2007 and lose in the debut match to Gregory iron. I cross Josh プロフィビション and the tag of the trainer and I march into the tag front, but lose consecutively afterwards. I started Gregory iron and rivalry after a tag straight defeat and continued disputing until August, 2008 and finished rivalry by victory of カルガノ finally. However, the backbone can do a small crack during the rivalry with the iron, and Gargano is absent.
I return in March, 2009 and I participate in the number one コンテンダー match which I bet the challenge right to PWO heavyweight class throne on at the same time and win. I challenge the PWO heavyweight class throne that the mat cross lasts in April, and I get throne, but I raise a difference with Josh of the partner during a game, and the relationship of mutual trust with Josh who continued for nearly three years collapses. And I start rivalry with Josh and I bet PWO heavyweight class throne at the rivalry most end of the war performed in A Coming of Age, and Wrestlelution 2 of August faces it and wins. I protect throne after throne acquisition many times over 2,010 years and outrun you. I attack it to a mat cross in June and start rivalry, and I bet a title in A Defining Moment, and Wrestlelution 3 of August faces it and I win and defend it. I defend it, but I am defeated by Marion phone Taine in March, 2011 and drop a title afterwards.
Professional wrestling Ohio changes its name in prime wrestling (Prime Wrestling) in early 2012. I challenge Prime heavyweight class throne (it was PWO heavyweight class throne, but the name of the title changed with the changing name of the group name, too) whom Jimmy Jacobs has in August and I win and acquire it.
Dragon Gate USA, EVOLVE (2009-2016)
I meet Colt Cavanna whom I was able to give an order to start cave サポルスキー which is a booker of former ROH which is looking for a wrestler by dragon gate USA (Dragon Gate USA) and evolution wrestling (Evolve Wrestling) during activity by all American wrestling (All American Wrestling) based in Chicago and appear on the dark match of Enter the Dragon which is PPV of dragon gate USA in the end of June. I participate in a dark match again in Untouchable of September. I participate in the tournament that I bet the first opening the freedom gate throne on in Freedom Fight of November, but am defeated in a qualifier. I participate in performance of the evolution wrestling for the first time in January, 2010 and break Chris ディッキンソン by a single match. I participate in PPV of ドラゲー USA, a dark match of Fearless one week later. And I contracted with dragon gate USA in May and was announced. I do zipper Taylor, ドレイク Jan garfish, 4way match, ドレイク and the single match of the Rich swan in CIMA and single match, September in July. I face Eric Canon and リコシェ in a tag with Taylor in Bushido:Code of the Warrior of the ドラゲー USA live pre-soft-headed view of late October and form Taylor, Rich swan and ロニン (Ronin) in victory, the PPV. I face Austin ray lease, Horiguchi spirit, リコシェ in ロニン in Freedom Fight of the next day and win.
When January, 2011 began, I participated in a tournament to opening the united gate throne, and I broke Shigeru Doi tree, リコシェ group and CIMA, a dragon kid group and went into the final, but broke it in Masato Yoshino, the PAC group, and it was not for united gate throne acquisition. I face CIMA, Shigeru Doi tree, リコシェ in CIMA and Mercury Rising 2011 in Open the South Gate of April. I participate in PPV of EVOLVE after PPV of ドラゲー USA. I face Elise, CIMA, Brodie Lee in partnership with swan, Masato Yoshino in Ailey's and play, Enter the Dragon Second Anniversary Celebration of June in Fearless of June. I face Doi with Tozawa in Way of the Ronin in Untouchable of September and express a throne challenge after a game in Way of the Ronin. I win against YAMATO in Freedom Fight of November and get opening the freedom gate throne.
I defend a title against リコシェ in January, 2012, but go for the injury of the back after a game at a hospital. I bet the opening the united gate throne who returns in March, and became the nominal position and I face リコシェ with Masato Yoshino, but, in partnership with zipper Taylor, am defeated. Taylor strikes Gargano after a game, and ロニン reaches dissolution. I receive a challenge of Masato Yoshino on the next day and bet freedom gate throne and face it and defend it. I receive a surprise attack of Taylor after a game, and it is decided to bet throne in Evolve 15 of June, and to face it. I defend it while suffering from back pain in Maine of Evolve 15. I receive a challenge of Tozawa in Untouchable of July and succeed in defense. A contract was approached WWE with after a game, but announced that I did ドラゲー USA and a contract with Evolve. I bet opening the freedom gate throne in Freedom Fight of November and defend it in Tozawa positive, AR Fox, a game with リコシェ against John Day screw in Evolve 17 of September. I continue defending it against John Day screw, Brian ケンドリック even after defense, 2013 begin in サミ キャリハン in Evolve 18 which is PPV of EVOLVE of December.
Power (2008.2010-2013.2016)
I spot it for power (Chikara) based in Philadelphia in June, 2008 and participate in the war and lose Marcie rocket with one round though I participate in Young Lions cup tournament. I participate in King of trio performed again for participation in a war, three days in 2010 as representative AIW, but I am defeated by the colony with one round and am defeated. I come to join F.I.S.T. of Icarus, Grand アクマ, zipper Taylor in a struggle on the second day. Chikarasaurus Rex: of July FIST faces CIMA, 望月成晃, supermarket Hsien Loong in King of Show, and because アクマ had its pinfall stolen by CIMA, Icarus and Taylor strike アクマ after a game, and Gargano joins F.I.S.T. exile instead from F.I.S.T. The participation of F.I.S.T. is because power gives a place of the activity to Gargano. I participated in Young Lions cup tournament in August and was active as F.I.S.T.
I participate in King of trio as F.I.S.T. in April, 2011 and I stay until the final, but am defeated. I start tag activity in June with zipper Taylor and I challenge Chikara Campeonatos de Parejas where jigsaw and microphone クアッケンブッシュ last in September and acquire it. I continued defending it until I was robbed of it by 3.0 of Scott Parker and Shane Matthews in March in the next year. Perform 3.0 and a rematch in the end of April, and get throne again, but Chikarasaurus Rex: of June I am robbed of title by young people Bucks in How to Hatch a Dinosaur. Sugar Dan Kay ton increases as the fourth member of F.I.S.T. in September. I go into King of trio until participation, the semifinals in the same month, but burst and yield to spectrum エンボイ (フライトメア, ultra man Thijs black, halo Wick).
Dragon gate
I make my debut at the first visit to Japan, a Japanese ring to participate in a 3-week tour of DRAGON GATE as ロニン (Ronin) which is a unit of DRAGON GATE USA in March, 2011. In partnership with zipper Taylor, Rich swan, I face the ember which is CIMA, Shigeru Doi tree, 谷嵜. I visit Japan as one of WORLD-1 INTERNATIONAL again in October, 2012. I cross understanding it with opening the freedom gate throne Saito "Jimmy" for the middle, and play wins and succeeds in the eighth defense.
WWE
In June, 2015, I participate in a try out of WWE [1]. I participate in the CWC that WWE and contract [2], WWE host on April 2, 2016. On July 21, I contract with WWE in full-time [3]. I am defeated with two rounds by the CWC in TJ Perkins.
In addition, Tranpedia is simply not responsible for any show is only by translating the writings of foreign licenses that are compatible with CC-BY-SA license information.
An Important Notice: The management index is securities report in the 151st in March, 2016 ※1: The number of employees is the number of the operation staff. The just-in-time employment staff (after retirement a re-employer, contracted employee) number lists the annual mean staff with an outside number.
It is a pharmaceutical company establishing the head office in Dosyomachi, Chuo-ku, Osaka-shi, Osaka of Japan, and Shionogi & Company, Limited (しおのぎせいやく, English :SHIONOGI & CO., LTD.) is a production sale maker mainly involving the ethical drugs. "Shionogi & Co., Ltd." or "Shionogi is used as an official company name abbreviated designation, too" [1]; [2].
The origin of the company name is associated with the name of Gisaburo Shiono of the founder [3]. The logo mark comes from the weight which was used to measure dosage with a balance exactly [4]. The corporate message is contribution するである with the health of all of you happily.
Table of contents
Company profile
It is founded, and I am by first generation, Gisaburo Shiono
Gisaburo Shiono of the founder opens the drugswholesale dealer "Gisaburo Shiono store" (1878) in Osaka, Doshomachi on March 17 in 1878. The business name of the shop of Naoko was "Gisaburo Shiono" only for personal names exactly. But I usually assume this "Gisaburo Shiono store" as seen in (cf. footnote) for "Shionogi 100 years" to distinguish the matter about the shop from justice Saburo individual [5]. When grandfather, first Kichibee [6] of justice Saburo appeared for the service at 12 years old in (the generous politics first year), an apothecary "Shiono shop wisteria soldier of the Imperial Guard" house of Doshomachi in 1789, the Shionos and relations with Doshomachi begin. "I, so to speak, distribute a noren", and first Kichibee will give Shiono shop Kichibee in という form as (culture five years), a cadet family of the Shiono-ya wisteria soldier of the Imperial Guard in 1808. It is time of following second generation Kichibee that I give "Shiono" family name (1872 (1872)). In addition, name in itself called the Shiono-ya was listed in the oldest document (1658 (Meiryaku era four years)) left in Doshomachi and boasted of the noren which was old in Doshomachi.
I am from the Japanese and Chinese medicines wholesale dealer to the 洋薬専門 maker
The beginning of establishment of a business was specialized in Japanese and Chinese medicines, but, with the Western medicine spread after the Meiji Restoration, demand for 洋薬 increases and I am going to handle only 洋薬 from (1886), Japanese and Chinese medicines specialty in 1886 and change it. And it produces "アンタチヂン" (digesting antacidum) as self new medicine first issue in (1909) in 1909 and sells it. I import and sell "salvarsan" (syphilis therapeutic drug) developed in Germany in 1909 in (1911) in 1911, the following day. Furthermore, production sells laxative "ラキサトール" in sequence sleep sedative "ドルミン" cardiotonic drug "ヂギタミン" in (1918) in 1918 in (1917) in 1917 in (1912) in 1912. In addition, as home pharmaceutical products, hemorrhoids medicine "カヴィドール" sells the products such as angina medicine "Hase rolls" medicine "ポンホリン" for exclusive use of the athlete's footdermatopathia new medicine "オイロ" in (1933) in 1933 in (1931) in 1931 in (1929) in 1929 in (1926) in 1926. In addition, I handled increase in blood medicine "マスチゲン" which Japan organ research institute (existing: Nippon Zoki Pharmaceutical Co., Ltd.) produced and got a license of the aspirin known as a representative medicine of German Bayer AG again and, as "Shiono aspirin tablet," I sold production in the country and have done it.
It is the factory completion, a corporation
As pharmaceutical products manufacturing facility, I build the Kuise factory [10] in (1922) in Pujiang experiment station [9], 1922 in (1921) in Shiono laboratory [8], 1921 in (1910) in Aioi factory [7], 1910 in (1892) in 1892. I hardened the changing of a name, the basics as the general pharmaceutical products production sale maker in the existing company name after the reorganization to the Tadashi Shiono store as the corporation Co., Ltd. (1919) in (1943) in 1943 in 1919 while developing a business activity to extend a market at the same time in the whole country.
Entry full-scale to an antibiotic
Just after World War II, Shionogi tried the antibiotic which became the flower-shaped product of the drug industry, development of penicillin, but stop because a technical aspect, fund side was inadequacy together; there was not it, and gave it up. However, an ethical drug market sprinkles antibiotic glory years in the late 1980s that I greeted without neglecting a study of the antimicrobial afterwards and records the sales amount first place with an antibiotic [11].
It is a cephalosporin-based (cephem system) antibiotic developed newly in the 1960s to have become the main force. In Shionogi, the release room introduced a few new product in sequence from United States, Eli Lilly of the manufacturer, too and manufactured it in-house. In addition, in addition, Shionogi grew up for the function as the importer in the big medical care medicine maker which had production (preparation) ability and study ability by having succeeded in a product made in wound of the new medicine in company Institute.
I am after the antibiotic decline to date
I assume an infectious disease domain, a cancerous sharp pain relaxation domain and a circulatory organ domain the main force as three pillars of the ethical drug market now in Shionogi.
On the other hand, it came to remain at the same level and largely decreased out of the concern for resistant bacteria after 1990 when the consumption of the infectious disease therapeutic drug was included in the 1980s. With it, the business results of Shionogi where had high antibiotic dependence suddenly dropped. It is Kress Thor to have saved it.
Kress Thor is Shionogi in (1991) for 1,991 years and, after a product made in wound, is the HMG-CoA reductase repressor that British AstraZeneca Corporation succeeded development in (1998) in 1998 (dyslipidemia therapeutic drug). The release in Japan is sold in approval and higher than in 80 countries in higher than in 100 countries (2009) as of October in 2009 that is (2005) in 2005. The royalty to enter Shionogi is big, and the company has achievements again after 2010.
In addition, Shionogi and the connection with the medical drug begin in having started production sale such as bulk such as morphine as one of five drug in (1948) in 1948. It releases MS コンチン lock (morphine controlled-release tablet) [12] along "WHO method cancer sharp pain cure" in (1989) in 1989. It releases オキシコンチン lock (oxycodone controlled-release tablet), (oxycodone powders) dispersing オキノーム more in (2007) in 2007 in (2003) in 2003 [13]. An MS コンチン lock and each oxycodone preparation are drugs becoming basic as "cancer-related sharp pain therapeutic drug" together (ingredient and agent type).
Industry's leading sales team
It is work of the salesmen (detailer) that send useful pharmaceutical products manufactured by various kinds of methods to the medical battle front. Speaking of business of Shionogi, I was known as the strongest sales team for antibiotic glory years. It is said that I made it for the doctor of the origin of prescription including document retrieval and the slide making for the presentation at the meeting to the limit. I already called the detailer detail man [14] [15] in those days in Shionogi. And, for example, adoption [16] did the way of thinking to become even if I led it of "the PK/PD theory" as help to perform explanation (detail) of a characteristic of the company antimicrobial logically quickly.
It is about for 1,993 years that I changed the name of the detailer to MR (medical representative) in the whole drug industry (1993). And, besides, the full-scale prohibition of the reception act is carried out (2012) from April in 2012, and, the reinforcement of the later government official ethic official regulations, rise of the woman MR, it changes into the relations with medical personnel (doctor in particular) and the MR rapidly. Meanwhile, I abolish the name of "the academic part" which belonged of the detail man (salesman for medical departments) in Shionogi from early 2012.
I handle many home pharmaceutical products with 洋薬転換後 of (Meiji 19), "Shionogi" brand [17] in 1886. When postwar period begins, I withdraw from the home medicine from these prewar days and raise a factory of Fukushima-ku, Osaka-shi (1961) in the research institute in 1961 and enter the antibiotic for hospitals in earnest. It shall be immovable in the share in the field of antibiotic.
Medicine manufacture for the treatment accounts 90% of pharmaceutical products to handle, and, as for the main force, a hyperlipidemia therapeutic drug, antibiotic is a cancer-related sharp pain therapeutic drug now. Speaking of an image of the company in the pharmaceutical products industry, I was known in "an antibiotic" (antibiotics) and "a strong sales team" and was the pharmaceutical products maker which had ever continued an excellent attack in the times of the antibiotic height of prosperity once (Takeda Pharmaceutical Co., Ltd.[18] was bigger, but, at the point of the scale, as for Takeda, old days say to the wide field that it is all azimuthal makers to prepare a product thoroughly make a great difference). However, in late years because there are rumors about the problem of resistant bacteria, and sales of antibiotic in itself blunt and greatly depended on an antibiotic, the future was anxious about by a fall in profits sudden at one time, but Kress Thor development and sales of the high fat blood medicine are restoring achievements rapidly after (2010) in successful 2010.
History
It is founded (1878) as Japanese and Chinese medicines wholesale dealer "Gisaburo Shiono store" in - Osaka, Doshomachi on March 17 in 1878
I am completed (1983) in Kanegasaki factory in - Isawa-gun, Iwate 1983
It merges and reorganizes 11 - wholesale subsidiaries (1998) on July 1 in 1998 and becomes Omori medicine Co., Ltd.
I establish production 100% subsidiary Musashi medicine manufacture Co., Ltd. of - pharmaceutical products given in trust (1998) on August 3 in 1998 (the company acquires land, a building, the facilities of the Novartis Pharma Saitama factory and I do business in) January in (1999 in 1999 and start).
Subsidiary, Shionogi USA are established (2001) in 2001 by - United States
I work, and - plant medicine business is transferred (2001) on October 1 in 2001 to Aventis crop science Shionogi Co., Ltd. (existing: Beyer crop science Co., Ltd.)
I carry out a clinical inspection section each to Shionogi biomedical Laboratories Co., Ltd. and transfer - animal medicine business (2002) to ベーリンガーインゲルハイムシオノギベトメディカ Co., Ltd. (existing: ベーリンガーインゲルハイムベトメディカジャパン Co., Ltd.) on April 1 in 2002
Omori medicine Co., Ltd. of - subsidiary is dissolved by unification (merger) with Suzuken Co., Ltd. (2002) on October 1 in 2002
It merges six subsidiaries which performed - real estate connection, asset management (2003) on April 1 in 2003
- industrial chemicals business is transferred (2003) on October 1 in 2003 to DSL. Japan Co., Ltd.
I sell our possession stocks of the - Shionogi biomedical Laboratories Co., Ltd. to Software Research Associate Elle Co., Ltd. (2007) on June 29 in 2007 (the company changes a business name of it to Software Research Associate L Kansai Co., Ltd. on August 1, the same year)
The first president-director (President detailer) is born other than a person of - establishment of a business (2008) on April 1 in 2008
I purchase major pharmaceutical company of - United States, rhinoceros L Farmer (2008) on August 1 in 2008
I establish Shionogi inc. summarizing Japan-U.S. national affairs business (2010) on July 1 in 2010
I make - Nichia Yakuhin Kogyo Co., Ltd. (I establish it by co-funding with Nichia Corp.) my subsidiary (2010) on November 1 in 2010, and the company is changed a business name of to シオノギファーマケミカル Co., Ltd.
I announce the voluntary recall saying that I am suspected of different pharmaceutical products having got mixed with Berwick's A plus and the Berwick's BE plus of the sale product which I shipped (2010) (2011) after November 25 for from January 25 to 2010 in 2011 [19].
I express my disapproval of additional tax and submit suit over a report leak problem of September 2 - said article (2016) in the Tokyo District Court for 2,016 years [23].
Infectious disease therapeutic drug of Shionogi
Import of salvarsan
It is considerably old that Shionogi came to handle an infectious disease therapeutic drug and imports and sells syphilis therapeutic drug "salvarsan" given a presentation at the meeting in (1910) in 1910 from German Hoechst AG of the origin of development at the end of the year. I continued the import and sales of the new medicine with the effect from the world drug industry and Shionogi began for the import of the gelatin capsule in a thing with pharmaceutical products major Eli Lilly of rice in (1909) in 1909, and had the relations that had a long it until import of hydrochloric acid vancomycin of (1991) other than the handling of ケフリン after the conclusion of the monopolistic dealership of Ilotycin アイロゾン import of insulin (1966) in 1991 in 1966 in (1953) in 1953 in (1923) in 1923 afterwards.
I am from penicillin development failure to Sinomin (sulfa drug) development
It was discovery, the development of the antibiotic which I did including penicillin that could say the turning point of the drug industry in the 20th century, but said with the star for the drug industry of Japan just after World War II about こと ペリシニン, and many companies started development and production including Shionogi. But, like the said article, Shionogi gives up development from immaturity and the lack of funds of the fermentation technology in (1949) in 1949. I manufactured Ilotycin of the macrolide derivative antibiotic which the fundamental researches of the antimicrobial itself were continued after it although penicillin development in the company came to a deadlock and introduced from above Eli Lilly in (1953) in 1953 in-house.
Furthermore, in company Institute, the wound produced sustained sulfa drug Sinomin (sulfamethoxazole) newly and started sale in (1959) in 1959. Sinomin was performed technical derivation [24] of in (1960) in 1960, the following day to 瑞, F. Hoffmamn-La Roche & Co. And it is done a product made in wound [25] as ST medical mixture (Bukta: sulfamethoxazole trimethoprim preparation) newly by the research institute and joint fundamental researches of the British welcome company Institute and is used widely all over the world afterwards until today.
I it as the antibiotic largest company
The ethical drug market greets antibiotic glory years in the late 1980s. The sales of the antibiotic of Shionogi reached the peak with it, too. The outlines of the sales amount of Shionogi at that time are as follows. In total sales approximately 200 billion yen [26] (a little over 5% of market shares), an antibiotic accounted for approximately nearly two-thirds of the whole sales (approximately 25% of market shares). The sales amount of the antibiotic representative in that was Kefral (internal use) approximately 60 billion yen, シオマリン (injection) approximately 40 billion yen. Only with these two items, overall sales; would almost occupy half. In addition, a ratio of pharmaceutical products for drugstore drugstores is approximately 3.5%. "Management of Shionogi" (cf. footnote)
It is a cephalosporin-based antibiotic mainly to have become the main force of the company. The cephalosporin-based (cephem system) antibiotic is a new antibiotic manufactured in the 1960s by United States, Eli Lilly. In Shionogi, I introduced Keflex of the internal use as an injectable agent in sequence from the company in (1970) in ケフロジン and 1970 in (1967) in ケフリン, 1967 in (1965) in 1965 and manufactured it in-house. And I succeed in a product made in new medicine wound afterwards in company Institute. It is the all injectable preparation which is シオマリン (the world's first oxacephem antibiotic) released in (1981) in 1981 and full Malin released in (1988) in 1988 (pro-oxacephem as for this). In addition, by the internal use, I introduce Kefral of the release from Eli Lilly secondary to Keflex (the said article) in 1981, and the wound produces Flomox of the release (1997) more in company Institute in 1997. All these are cephem antibiotic, too.
I introduce hydrochloric acid vancomycin (glycopeptide-based antibiotic) from Eli Lilly in (1991) in 1991 and, for main antimicrobe medicine except the cephem antibiotic, begin to sell it. Furthermore, in company Institute, I succeed in a product made in wound of フィニバックス (carbapenem-based antibiotic) and start sale in (2005) in 2005. In addition, I start sale of Rapiacta (antiinfluenza virus agent) (2010) at an end in 2010. Shionogi introduces it from the American venture company and developed it in Japan, and it is the nation's first neuraminidase inhibitor and is the world's first injection preparation.
In addition, there is fragile (metronidazole). It is an antitrichomonal agent developed in Buddha, Rhone Poulenc roller company Institute in 1957. It was (2005) (1961) in the country in beginning to sell, 2005 in 1961, and an effect, an effect about "Helicobacter pylori sanitization" (the second sanitization) and a use, a dose were approved more, and the range of an effect, the effect about the sanitization was enlarged in (2010) in 2010. Furthermore, an effect, the effect of "the bacterial vagina symptom" and a use, a dose were approved more in (2012) in 2012 by well-known application.
I found an infectious disease medicine proper use promotion room and it
In Shionogi, I found "infectious disease medicine proper use promotion room" [27] in a purpose, "I support the making of environment that I control the appearance of resistant bacteria by promoting proper use of the antimicrobial, and existing antimicrobial can effectively utilize" (2010) in July in 2010. The domain of the infectious disease treatment called the appearance of the resistant bacteria for release and that of new medicine, so to speak, repeated "a vicious circle". When it was the 1980s, overuse of the medicine and the relations with the appearance of resistant bacteria began to be concerned about, and the consumption of the infectious disease medicine was half as follows at the peak in about 2010 in the late 1980s. Meanwhile, major companies of the world withdraw from the antimicrobial market, and it is in a situation that almost none of the release of the new medicine can anticipate it (one side, the scale of the lifestyle-related disease domain become big).
However, the menaces of resistant bacteria rather increase. For example, of the nosocomial infection due to multiple drug resistant bacteria is recognized as a social issue or is appearances of the new influenza virus. Shionogi is a development maker of a few infectious disease therapeutic drugs now in the world. The future trend of "the infectious disease medicine proper use promotion room" attracts attention.
Sponsor activity
Music fair
It lasts more than 40 years and continues a sponsor of music channel "music fair" (from 2001 (2001) April 7 to 2008 (2008) September 27 "music fair 21") broadcasted with a part of the subsidiary ofFuji TV (broadcasts 17 stations net, 11 stations fault as of April, 2016) until today in 1964 by broadcast launch of (1964). Even if it is the trouble in 2011 mentioned above, I went as usual, but I drink it for broadcast from influence of the 2011 off the Pacific coast of Tohoku Earthquake (the Great East Japan Earthquake) (2011) on March 19 in 2011 and restrain myself from a sponsor and will cover it in CM of the AC Japan.
For a long time, I broadcasted it at the company CM center and, from the 1970s, I appointed Keiichi Noda → Shusei Nakamura of the narrator in voice actors and was labelled saying Shionogi was steady today to be healthy, and to serve it, "it continues making an effort of you" and broadcasted the advertising of the over-the-counter drug (OTC pharmaceutical products) to get as a set with ポポン S of the multivitamin, pylon capsule (there has not been broadcast now in a season except the winter when there was relatively still little cold pylon MX) of the synthesis cold preparation (capsule), three of the セデス A lock of the alleviation of fever pain-killer (now a new セデス lock) in a drugstore in a mini-infomercial form (Fusako Miyazaki → Haruko Kitahama was in charge of the narration about the introduction of the medicine). Called CM speaking the explanation about the weight mark that is a company badge of Shionogi in the ending after the main volume was constituted.
なお、2001年（平成13年）の『ミュージックフェア21』のスタートと同時に、同社のローマ字表記であるSHIONOGIから「SONG（ソング）」を取り上げた、歌とクスリをテーマにした「SONG For You（ソング・フォー・ユー）」という企業CMを放送中である（三原徹司 → 磯部弘のナレーション付）。この時はこれに加え、「SONG For You」のキャッチフレーズが、個々の製品CMにも使用されていたが、2013年6月に当社の公式サイト及びセデス・ハイのCMがリニューアルしたことを皮切りに、この前述の企業CM及びポポンSプラスのCMを除いてキャッチフレーズを外していた。2015年3月以降は「クッションコレクトEZ」のみだったが、同年11月は「コレクトXYLクリーム／さわやかコレクトW抗菌」のCMにもキャッチフレーズを付加しており、2016年4月以降はシオノギ製薬のロゴ部分をシオノギヘルスケアにさし替えしただけであるためキャッチフレーズはそのままである。
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